Literature DB >> 29946362

Erratum: Publisher Correction: Is DNA methylation the new guardian of the genome?

Robert M Hoffman1,2.   

Abstract

[This corrects the article DOI: 10.1186/s13039-017-0314-8.].

Entities:  

Year:  2018        PMID: 29946362      PMCID: PMC6001167          DOI: 10.1186/s13039-018-0385-1

Source DB:  PubMed          Journal:  Mol Cytogenet        ISSN: 1755-8166            Impact factor:   2.009


Correction

In the original publication of this article [1] the figures and the captions of 3 figures do not match correctly due to a typographical error. In this correction article the corrected figures and captions for Figs. 1, 2 and 3 are shown.
Fig. 1

Rates of transmethylation of human tumor cell lines and normal human fibroblast cell strains. All cells were labeled with 100 μM [35S]-methionine-containing medium (25 μCi/ml) for 24 h. Periodateoxidized 3-deazaadenosine was added to a concentration of 10 µM and the accumulation of [35S] AdoHcy was measured at half- hour intervals. Solid lines are human cancer cell lines. Dashed lines are human normal cell strains [38]

Fig. 2

Recombinant methioninase (rMETase) traps cancer cells in S/G2 phase. Time-course imaging of HeLa-FUCCI cells treated with rMETase (1.0 unit/ml). Kinetics of rMETase trapping of cells in S/G2. Images were acquired with the FV1000 confocal microscope (Olympus, Tokyo, Japan). In the FUCCI system, the cells in G0/G1, S, or G2/M phases appear red, yellow, or green, respectively [66]

Fig. 3

Efficacy of recombinant methioninase (rMETase) on growth of human colon tumors HCT 15 in nude mice. rMETase (5 or 10 units/g every 8 h) was administered by i.p. injection in nude mice with human colon tumor HCT 15, growing s.c. [54]

Rates of transmethylation of human tumor cell lines and normal human fibroblast cell strains. All cells were labeled with 100 μM [35S]-methionine-containing medium (25 μCi/ml) for 24 h. Periodateoxidized 3-deazaadenosine was added to a concentration of 10 µM and the accumulation of [35S] AdoHcy was measured at half- hour intervals. Solid lines are human cancer cell lines. Dashed lines are human normal cell strains [38] Recombinant methioninase (rMETase) traps cancer cells in S/G2 phase. Time-course imaging of HeLa-FUCCI cells treated with rMETase (1.0 unit/ml). Kinetics of rMETase trapping of cells in S/G2. Images were acquired with the FV1000 confocal microscope (Olympus, Tokyo, Japan). In the FUCCI system, the cells in G0/G1, S, or G2/M phases appear red, yellow, or green, respectively [66] Efficacy of recombinant methioninase (rMETase) on growth of human colon tumors HCT 15 in nude mice. rMETase (5 or 10 units/g every 8 h) was administered by i.p. injection in nude mice with human colon tumor HCT 15, growing s.c. [54] The publisher apologizes to the readers and authors for the inconvenience.
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Review 1.  Is DNA methylation the new guardian of the genome?

Authors:  Robert M Hoffman
Journal:  Mol Cytogenet       Date:  2017-04-04       Impact factor: 2.009

  1 in total

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