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Literature DB >> 29945208

An Overview of Molecular Profiles in Ulcerative Colitis-Related Cancer.

Meng Xue^1,2, Liuhong Shi³, Weijia Wang⁴, Shujie Chen⁵, Liangjing Wang^1,2.

Abstract

Ulcerative colitis (UC) is an independent risk factor of colorectal cancer (CRC). Both genetic and epigentic events induce a unique molecular profile during the development from UC to UC-related CRC (UCRC). These molecular changes play varied roles in DNA repair, immune response, cell metabolism, and interaction with the microbiota during the carcinogenesis process. This review will systmatically discuss the molecular characteristics of UCRC and point out the future perspectives in this research field.

Entities: Disease

Keywords: colorectal cancer; epigenetics; genetics; gut microbiota; molecule; ulcerative colitis

Mesh：

Year: 2018 PMID： 29945208 DOI： 10.1093/ibd/izy221

Source DB: PubMed Journal: Inflamm Bowel Dis ISSN： 1078-0998 Impact factor: 5.325

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Cited

4 in total

An Overview of Molecular Profiles in Ulcerative Colitis-Related Cancer.

1. Transcription Factors That Regulate the Pathogenesis of Ulcerative Colitis.

2. ELTD1 promotes invasion and metastasis by activating MMP2 in colorectal cancer.

3. Retinoid acid induced 16 deficiency aggravates colitis and colitis-associated tumorigenesis in mice.

4. Artesunate alleviates the inflammatory response of ulcerative colitis by regulating the expression of miR-155.