Simone Cazzaniga1,2,3, Barbara K Ballmer-Weber4,5,6, Nora Gräni4, Philippe Spring7, Andreas Bircher8, Mark Anliker9,10, Anne-Katharina Sonntag11, Pierre Piletta12, Caroline Huber12,13, Thomas L Diepgen14, Christian Apfelbacher15, Luigi Naldi2,16, Luca Borradori1, Dagmar Simon1. 1. Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland. 2. Centro Studio, Italian Group for Epidemiological Research in Dermatology (GISED), Bergamo, Italy. 3. Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland. 4. Department of Dermatology, University Hospital Zurich, Zurich, Switzerland. 5. Faculty of Medicine, University of Zurich, Zurich, Switzerland. 6. Allergy Unit, Clinic of Dermatology and Allergology, Cantonal Hospital St Gallen, St. Gallen, Switzerland. 7. Department of Dermatology, University Hospital of Lausanne CHUV, Lausanne, Switzerland. 8. Department of Dermatology, University Hospital Basel, Basel, Switzerland. 9. Clinic of Dermatology and Allergology, Cantonal Hospital St Gallen, St Gallen, Switzerland. 10. Hautärzte am Graben, Winterthur, Switzerland. 11. Department of Dermatology, Cantonal Hospital Aarau, Aarau, Switzerland. 12. Department of Dermatology, Geneva University Hospitals (HUG), Geneva, Switzerland. 13. Dermatology Office, Versoix, Switzerland. 14. Department of Clinical Social Medicine, Occupational and Environmental Dermatology, University Hospital, Ruprecht Karls University, Heidelberg, Germany. 15. Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany. 16. Department of Dermatology, San Bortolo Hospital, Vicenza, Italy.
Abstract
BACKGROUND: Hand eczema (HE) is common and may follow a chronic disease course. So far, prospective studies investigating the risk factors for disease progression as a prerequisite for targeted prevention are scarce. OBJECTIVE: To evaluate the overall association of HE-associated factors with clinical and quality of life (QoL) improvement during a follow-up of 2 years. METHODS: Data of the prospective patient cohort (N = 199) followed by the Swiss chronic HE (CHE) registry on long-term patient management (CARPE-CH) were analysed by means of both classic regression and semantic map analyses. RESULTS: Both severity of HE and QoL significantly improved over the period of 2 years (P < .001). However, 20% of patients had moderate to severe HE after 2 years of follow-up. As factors associated with an unfavourable CHE clinical course and QoL, environmental exposures, male sex, occupational skin disease, job loss or change at baseline, allergic contact dermatitis, a chronic disease course, palmar localization and widespread eczema were identified. CONCLUSIONS: Analysis of prospective data from CARPE-CH shows a complex pattern of associations among variables as shown by semantic map and classic statistical analyses. Factors related to occupational exposure had the highest impact on CHE.
BACKGROUND:Hand eczema (HE) is common and may follow a chronic disease course. So far, prospective studies investigating the risk factors for disease progression as a prerequisite for targeted prevention are scarce. OBJECTIVE: To evaluate the overall association of HE-associated factors with clinical and quality of life (QoL) improvement during a follow-up of 2 years. METHODS: Data of the prospective patient cohort (N = 199) followed by the Swiss chronic HE (CHE) registry on long-term patient management (CARPE-CH) were analysed by means of both classic regression and semantic map analyses. RESULTS: Both severity of HE and QoL significantly improved over the period of 2 years (P < .001). However, 20% of patients had moderate to severe HE after 2 years of follow-up. As factors associated with an unfavourable CHE clinical course and QoL, environmental exposures, male sex, occupational skin disease, job loss or change at baseline, allergic contact dermatitis, a chronic disease course, palmar localization and widespread eczema were identified. CONCLUSIONS: Analysis of prospective data from CARPE-CH shows a complex pattern of associations among variables as shown by semantic map and classic statistical analyses. Factors related to occupational exposure had the highest impact on CHE.
Authors: Sharara Shakik; Victoria Arrandale; Dorothy Linn Holness; Jill S MacLeod; Christopher B McLeod; Alice Peter; Paul A Demers Journal: Occup Environ Med Date: 2019-07-18 Impact factor: 4.402
Authors: Laura Loman; Marjolein J Brands; Anna A L Massella Patsea; Klaziena Politiek; Bernd W M Arents; Marie L A Schuttelaar Journal: Contact Dermatitis Date: 2022-04-02 Impact factor: 6.419