Literature DB >> 2994175

Prostaglandins and their precursors can modify genetic damage-induced by gamma-radiation and benzo(a)pyrene.

U N Das, G Ramadevi, K P Rao, M S Rao.   

Abstract

Experiments were performed to study the effect of various prostaglandins (PGs) and their precursors, gamma-linolenic acid (GLA) and arachidonic acid (AA) on gamma-radiation and benzo (a) pyrene (BP)-induced genetic damage to the bone marrow cells of mice, using the sensitive micronucleus (MN) test. Thromboxane B2 prostaglandin E1 and GLA completely prevented BP-induced and reduced to a great degree radiation-induced genetic damage, where as PGE2, PGF2 alpha and AA were without any effect. Since GLA and AA are widely distributed in the cell membranes, and as PGs can be formed virtually in response to any type of stimulus, it is likely that GLA and PGE1 may function as endogenous anti-mutagenic chemicals.

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Year:  1985        PMID： 2994175     DOI： 10.1016/0090-6980(85)90216-3

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  8 in total

1.  Modification of benzo(a)pyrene induced chromosomal damage in mouse bone marrow by vitamin A.

Authors:  K P Rao; B D Nandan
Journal:  Bull Environ Contam Toxicol       Date:  1990-12       Impact factor: 2.151

Review 2.  Pro- and anti-inflammatory bioactive lipids imbalance contributes to the pathobiology of autoimmune diseases.

Authors:  Undurti N Das
Journal:  Eur J Clin Nutr       Date:  2022-06-14       Impact factor: 4.016

3.  Modulation of pro-inflammatory and pro-resolution mediators by γ-linolenic acid: an important element in radioprotection against ionizing radiation.

Authors:  Rangachar Poorani; Anant N Bhatt; Undurti N Das
Journal:  Arch Med Sci       Date:  2020-01-29       Impact factor: 3.318

Review 4.  "Cell Membrane Theory of Senescence" and the Role of Bioactive Lipids in Aging, and Aging Associated Diseases and Their Therapeutic Implications.

Authors:  Undurti N Das
Journal:  Biomolecules       Date:  2021-02-08

5.  Gamma-Linolenic Acid (GLA) Protects against Ionizing Radiation-Induced Damage: An In Vitro and In Vivo Study.

Authors:  Poorani Rengachar; Anant Narayan Bhatt; Sailaja Polavarapu; Senthil Veeramani; Anand Krishnan; Monika Sadananda; Undurti N Das
Journal:  Biomolecules       Date:  2022-06-07

6.  Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro.

Authors:  Jinfeng Dai; Junhui Shen; Wensheng Pan; Shengrong Shen; Undurti N Das
Journal:  Lipids Health Dis       Date:  2013-05-10       Impact factor: 3.876

7.  Differential action of polyunsaturated fatty acids and eicosanoids on bleomycin-induced cytotoxicity to neuroblastoma cells and lymphocytes.

Authors:  Sailaja Polavarapu; Bilikere S Dwarakanath; Undurti N Das
Journal:  Arch Med Sci       Date:  2017-12-19       Impact factor: 3.318

Review 8.  Ageing: Is there a role for arachidonic acid and other bioactive lipids? A review.

Authors:  Undurti N Das
Journal:  J Adv Res       Date:  2018-02-15       Impact factor: 10.479
  8 in total

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