Martino Pepe1, Domenico Zanna1, Alessandro Cafaro2, Alfredo Marchese3, Francesco Addabbo4, Eliano Pio Navarese5, Massimo Napodano6, Annagrazia Cecere7, Fabrizio Resta8, Valeria Paradies9, Alessandro Santo Bortone10, Stefano Favale1. 1. Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy. 2. Department of Cardiology, General Hospital "F. Miulli", Acquaviva delle Fonti, Bari, Italy. 3. Department of Cardiology, Anthea Hospital, GVM Care & Research, Bari, Italy. 4. Department of Biomedical Sciences & Human Oncology, University of Bari Medical School, Bari, Italy. 5. Department of Internal Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, Heinrich-Heine-University, Düsseldorf, Germany. 6. Department of Cardiac, Thoracic and Vascular Sciences, Hospital-University of Padova, Padova, Italy. 7. Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy. Electronic address: agcecere@gmail.com. 8. Department of Cardiology, "Santa Maria" Hospital, GVM Care & Research, Bari, Italy. 9. Department of Cardiology, Maasstad Ziekenhuis Hospital, Rotterdam, Netherlands. 10. Division of Heart Surgery, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy.
Abstract
AIMS: Hyperglycemia is frequent in patients with ST elevation myocardial infarction (STEMI) and is associated with adverse outcome. Aim of our study was to evaluate the correlation between admission plasma glucose level (PGL) and coronary arteries flow velocity. METHODS: We enrolled 149 STEMI patients successfully treated with primary percutaneous coronary intervention (pPCI). The study population was divided into two groups based on PGL (< or >140 mg/dl) and on history of diabetes, and the groups compared in terms of corrected TIMI frame count (cTFC). RESULTS: Hyperglycemic patients had a significantly higher cTFC in both the culprit (p < 0.0001) and non-culprit vessel (p: 0.0002); diabetes history impairs as well cTFC of the culprit (p < 0.0001) and non-culprit vessel (p: 0.0001). Within the subpopulation of diabetic patients hyperglycemic ones showed higher cTFC in both the culprit (p 0.0013) and non-culprit vessel (p: 0.0006). Moreover in the whole population cTFC values of both arteries increase linearly with the increment of admission PGL. CONCLUSIONS: Admission PGL affects coronary flow of both culprit and non-culprit vessel. The impairment of coronary flow is also demonstrated in known diabetic patients, suggesting to consider hyperglycemia an additional risk factor. We finally demonstrated for the first time a positive linear relationship between PGL and cTFC.
AIMS: Hyperglycemia is frequent in patients with ST elevation myocardial infarction (STEMI) and is associated with adverse outcome. Aim of our study was to evaluate the correlation between admission plasma glucose level (PGL) and coronary arteries flow velocity. METHODS: We enrolled 149 STEMI patients successfully treated with primary percutaneous coronary intervention (pPCI). The study population was divided into two groups based on PGL (< or >140 mg/dl) and on history of diabetes, and the groups compared in terms of corrected TIMI frame count (cTFC). RESULTS:Hyperglycemicpatients had a significantly higher cTFC in both the culprit (p < 0.0001) and non-culprit vessel (p: 0.0002); diabetes history impairs as well cTFC of the culprit (p < 0.0001) and non-culprit vessel (p: 0.0001). Within the subpopulation of diabeticpatientshyperglycemic ones showed higher cTFC in both the culprit (p 0.0013) and non-culprit vessel (p: 0.0006). Moreover in the whole population cTFC values of both arteries increase linearly with the increment of admission PGL. CONCLUSIONS: Admission PGL affects coronary flow of both culprit and non-culprit vessel. The impairment of coronary flow is also demonstrated in known diabeticpatients, suggesting to consider hyperglycemia an additional risk factor. We finally demonstrated for the first time a positive linear relationship between PGL and cTFC.
Authors: Han Wu; Ran Li; Kun Wang; Dan Mu; Jian-Zhou Chen; Xuan Wei; Xue Bao; Zhong-Hai Wei; Jun Xie; Biao Xu Journal: Cardiol Res Pract Date: 2020-09-26 Impact factor: 1.866