| Literature DB >> 29937060 |
Gaëtan Maertens1, Oscar M Saavedra1, Vito Vece1, Miguel A Vilchis Reyes1, Sofiane Hocine1, Esat Öney1, Bertrand Goument2, Olivier Mirguet2, Arnaud Le Tiran2, Philippe Gloanec2, Stephen Hanessian3.
Abstract
We have developed versatile methods toward the synthesis of a variety of piperidine/piperazine bridged isosteres of pridopidine. The compounds were assessed against the D2 receptor in agonist and antagonist modes and against the D4 receptor in agonist mode. hERG Binding and the ADME profiles were studied.Entities:
Keywords: C-arylation; Constrained amines; Dopaminergic activity; Oxabicyclic piperazines; Oxabicyclic piperidines
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Year: 2018 PMID： 29937060 DOI： 10.1016/j.bmcl.2018.06.038
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823