Francesca Perondi1, Ilaria Lippi1, Gianila Ceccherini1, Veronica Marchetti1, Lucrezia Bernicchi1, Grazia Guidi1.
Abstract
OBJECTIVE: To investigate prognostic models in a cohort of dogs with acute kidney injury (AKI) and acute on chronic kidney disease (AKI/CKD) managed by hemodialysis.
DESIGN: Retrospective study from July 2011 to November 2014.
SETTING: University Veterinary Teaching Hospital. ANIMALS: Forty dogs with historical, clinical, imaging, and laboratory findings consistent with AKI or AKI/CKD managed with intermittent hemodialysis were included.
INTERVENTIONS: Scoring system models previously established by Segev et al for outcome prediction in dogs with AKI were applied to all dogs.
RESULTS: Models A, B, and C correctly classified outcomes in 68%, 83%, and 85% of cases, respectively. In our cohort Model A showed sensitivity of 58% and specificity of 86%, Model B showed sensitivity of 79% and specificity of 87%, Model C showed sensitivity of 86% and specificity of 84%. The presence of anuria (P < 0.0002), respiratory complications (P < 0.0001), disseminated intravascular coagulation (DIC) (P = 0.0004), grade of AKI (P = 0.0023), pancreatitis (P = 0.0001), and systemic inflammatory response syndrome (SIRS) (P = 0.0001) was significantly higher in nonsurvivors compared with survivors.
CONCLUSIONS: In our cohort of patients, Segev's model C showed the best sensitivity and specificity for predicting prognosis, while model A had lower sensitivity. In our cohort of dialysis patients, the presence of respiratory complications, DIC, SIRS, and pancreatitis at hospitalization, were correlated with a poor prognosis. © Veterinary Emergency and Critical Care Society 2018.
OBJECTIVE: To investigate prognostic models in a cohort of dogs with acute kidney injury (AKI) and acute on chronic kidney disease (AKI/CKD) managed by hemodialysis.
DESIGN: Retrospective study from July 2011 to November 2014.
SETTING: University Veterinary Teaching Hospital. ANIMALS: Forty dogs with historical, clinical, imaging, and laboratory findings consistent with AKI or AKI/CKD managed with intermittent hemodialysis were included.
INTERVENTIONS: Scoring system models previously established by Segev et al for outcome prediction in dogs with AKI were applied to all dogs.
RESULTS: Models A, B, and C correctly classified outcomes in 68%, 83%, and 85% of cases, respectively. In our cohort Model A showed sensitivity of 58% and specificity of 86%, Model B showed sensitivity of 79% and specificity of 87%, Model C showed sensitivity of 86% and specificity of 84%. The presence of anuria (P < 0.0002), respiratory complications (P < 0.0001), disseminated intravascular coagulation (DIC) (P = 0.0004), grade of AKI (P = 0.0023), pancreatitis (P = 0.0001), and systemic inflammatory response syndrome (SIRS) (P = 0.0001) was significantly higher in nonsurvivors compared with survivors.
CONCLUSIONS: In our cohort of patients, Segev's model C showed the best sensitivity and specificity for predicting prognosis, while model A had lower sensitivity. In our cohort of dialysis patients, the presence of respiratory complications, DIC, SIRS, and pancreatitis at hospitalization, were correlated with a poor prognosis. © Veterinary Emergency and Critical Care Society 2018.
Entities:
Keywords:
AKI; IRIS grading; dogs; hemodialysis; prognosis
Mesh：
Year: 2018
PMID： 29936707 DOI： 10.1111/vec.12736
Source DB: PubMed Journal: J Vet Emerg Crit Care (San Antonio) ISSN： 1476-4431