Shintaro Shiba1, Masahiko Okamoto2, Hiroki Kiyohara3, Naoko Okano1, Yuya Yoshimoto1, Hiroto Murata4, Daisuke Irie5, Hiroyuki Katoh6, Takashi Nakano1. 1. Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan. 2. Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan okamott@gunma-u.ac.jp. 3. Department of Radiation Oncology, Japanese Red Cross Maebashi Hospital, Gunma, Japan. 4. Hospital, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan. 5. Department of Radiation Oncology, Nara Medical University Graduate School of Medicine, Nara, Japan. 6. Department of Radiation Oncology, Kanagawa Cancer Center, Yokohama, Japan.
Abstract
BACKGROUND/AIM: The clinical outcomes of post-mastectomy radiation therapy (PMRT) without bolus remain to be fully examined, so that we evaluated clinical outcomes of PMRT without bolus and to measure the chest-wall dose surface histogram (DSH) parameters. PATIENTS AND METHODS: Fifty-two patients with breast cancer who received PMRT without bolus were retrospectively analyzed. DSH values of the percentage of maximum dose (Dmax) were measured. RESULTS: All patients completed the treatment; the median follow-up period was 22.1 months. The 2-year overall survival and local control rates were 85% and 95%. Five patients developed grade 2 acute radiation dermatitis, and none developed grade 2 or higher late radiation dermatitis. The median Dmax in patients who developed grade 0-1 and grade 2 acute radiation dermatitis was 5,178 and 5,365 cGy (p=0.03). CONCLUSION: PMRT without bolus resulted in a low frequency of grade 2 or higher radiation dermatitis without increasing locoregional recurrences, and the Dmax was the contributing factor for developing acute radiation dermatitis. Copyright
BACKGROUND/AIM: The clinical outcomes of post-mastectomy radiation therapy (PMRT) without bolus remain to be fully examined, so that we evaluated clinical outcomes of PMRT without bolus and to measure the chest-wall dose surface histogram (DSH) parameters. PATIENTS AND METHODS: Fifty-two patients with breast cancer who received PMRT without bolus were retrospectively analyzed. DSH values of the percentage of maximum dose (Dmax) were measured. RESULTS: All patients completed the treatment; the median follow-up period was 22.1 months. The 2-year overall survival and local control rates were 85% and 95%. Five patients developed grade 2 acute radiation dermatitis, and none developed grade 2 or higher late radiation dermatitis. The median Dmax in patients who developed grade 0-1 and grade 2 acute radiation dermatitis was 5,178 and 5,365 cGy (p=0.03). CONCLUSION: PMRT without bolus resulted in a low frequency of grade 2 or higher radiation dermatitis without increasing locoregional recurrences, and the Dmax was the contributing factor for developing acute radiation dermatitis. Copyright
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