Han Soo Yoo1, Seun Jeon2, Seok Jong Chung1, Mijin Yun3, Phil Hyu Lee1, Young Ho Sohn1, Alan C Evans2, Byoung Seok Ye4. 1. Department of Neurology, Yonsei University College of Medicine, Seoul, Korea. 2. McGill Center for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, Canada. 3. Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Korea. 4. Department of Neurology, Yonsei University College of Medicine, Seoul, Korea. Electronic address: romel79@gmail.com.
Abstract
INTRODUCTION: Olfactory dysfunction is common in Alzheimer's disease- and Lewy body-related disorders, but its neural correlates have not been clearly elucidated. METHODS: We retrospectively recruited 237 patients with Alzheimer's disease-related cognitive impairment (ADCI) and 217 with Lewy body-related cognitive impairment (LBCI). They were identically evaluated using the Cross-Cultural Smell Identification Test, neuropsychological tests, and brain magnetic resonance imaging. RESULTS: LBCI had more severe olfactory dysfunction than ADCI. Patients with more severe cognitive dysfunction had worse olfactory function in both groups. In ADCI, lower Cross-Cultural Smell Identification Test scores correlated with a lower cortical thickness in brain regions typically affected in Alzheimer's disease, most prominently in the right parahippocampal cortex, whereas in LBCI, the scores correlated with white matter abnormalities in regions vulnerable to Lewy body, including subcortical regions of the orbitofrontal and frontoparietal cortices. DISCUSSION: Our results suggest that cortical atrophy in ADCI and white matter abnormalities in LBCI play important roles in olfactory dysfunction.
INTRODUCTION:Olfactory dysfunction is common in Alzheimer's disease- and Lewy body-related disorders, but its neural correlates have not been clearly elucidated. METHODS: We retrospectively recruited 237 patients with Alzheimer's disease-related cognitive impairment (ADCI) and 217 with Lewy body-related cognitive impairment (LBCI). They were identically evaluated using the Cross-Cultural Smell Identification Test, neuropsychological tests, and brain magnetic resonance imaging. RESULTS: LBCI had more severe olfactory dysfunction than ADCI. Patients with more severe cognitive dysfunction had worse olfactory function in both groups. In ADCI, lower Cross-Cultural Smell Identification Test scores correlated with a lower cortical thickness in brain regions typically affected in Alzheimer's disease, most prominently in the right parahippocampal cortex, whereas in LBCI, the scores correlated with white matter abnormalities in regions vulnerable to Lewy body, including subcortical regions of the orbitofrontal and frontoparietal cortices. DISCUSSION: Our results suggest that cortical atrophy in ADCI and white matter abnormalities in LBCI play important roles in olfactory dysfunction.
Authors: Seok Jong Chung; Yang Hyun Lee; Han Soo Yoo; Young H Sohn; Byoung Seok Ye; Jungho Cha; Phil Hyu Lee Journal: Eur J Nucl Med Mol Imaging Date: 2019-04-12 Impact factor: 9.236
Authors: Han Soo Yoo; Seun Jeon; Enrica Cavedo; MinJin Ko; Mijin Yun; Phil Hyu Lee; Young H Sohn; Michel J Grothe; Stefan Teipel; Harald Hampel; Alan C Evans; Byoung Seok Ye Journal: Neurology Date: 2021-12-30 Impact factor: 9.910
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