Andrea Corsonello1, Regina Roller-Wirnsberger2, Mirko Di Rosa3, Paolo Fabbietti3, Gerhard Wirnsberger2, Tomasz Kostka4, Agnieszka Guligowska4, Lisanne Tap5, Francesco Mattace-Raso5, Pedro Gil6, Lara Guardado-Fuentes6, Itshak Meltzer7, Ilan Yehoshua8, Rada Artzi-Medevdik9, Francesc Formiga10, Rafael Moreno-González10, Christian Weingart11, Ellen Freiberger11, Johan Ärnlöv12, Axel C Carlsson13, Fabrizia Lattanzio3. 1. Italian National Research Center on Aging (INRCA), Ancona, Fermo and Cosenza, Italy. Electronic address: andrea_corsonello@tin.it. 2. Department of Internal Medicine, Medical University of Graz, Austria. 3. Italian National Research Center on Aging (INRCA), Ancona, Fermo and Cosenza, Italy. 4. Department of Geriatrics, Healthy Ageing Research Centre, Medical University of Lodz, Poland. 5. Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands. 6. Department of Geriatric Medicine, Hospital Clinico San Carlos, Madrid, Spain. 7. The Recanati School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel. 8. Maccabi Healthcare Services Southern Region, Israel. 9. The Recanati School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel; Maccabi Healthcare Services Southern Region, Israel. 10. Geriatric Unit, Internal Medicine Department and Nephrology Department, Bellvitge University Hospital - IDIBELL - L'Hospitalet de Llobregat, Barcelona, Spain. 11. Department of General Internal Medicine and Geriatrics, Krankenhaus Barmherzige Brüder Regensburg and Institute for Biomedicine of Aging, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany. 12. Department of Medical Sciences, Uppsala University, Sweden; School of Health and Social Studies, Dalarna University, Falun, Sweden; Division of Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden. 13. Department of Medical Sciences, Uppsala University, Sweden; Division of Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Abstract
BACKGROUND: The association between chronic kidney disease (CKD) and functional status may change as a function of the equation used to estimate glomerular filtration rate (eGFR). We reviewed the predictive value of different eGFR equations in regard to frailty and disability outcomes. METHODS: We searched Pubmed from inception to March 2018 for studies investigating the association between eGFR and self-reported and/or objective measures of frailty or disability. Cross-sectional and longitudinal studies were separately analysed. RESULTS: We included 16 studies, one of which reporting both cross-sectional and longitudinal data. Three out of 7 cross-sectional studies compared different eGFR equations in regard to their association with functional status: two studies showed that cystatin C-based, but not creatinine-based eGFR may be associated with hand-grip strength or frailty; another study showed that two different creatinine-based eGFR equations may be similarly associated with disability. Four out of 10 longitudinal studies provided comparative data: two studies reported similar association with disability for different creatinine-based eGFR equations; one study showed that creatinine-based eGFR was not associated with frailty, but a not significant trend for association was observed with cystatin C-based eGFR; one study showed that cystatin C-based but not creatinine-based eGFR may predict incident mobility disability, while both methods may predict gait speed decline. High heterogeneity was observed in regard to confounders included in reviewed studies. None of them included the most recently published equations. CONCLUSION: Available data do not support the superiority of one of the eGFR equations in terms of measuring or predicting functional decline.
BACKGROUND: The association between chronic kidney disease (CKD) and functional status may change as a function of the equation used to estimate glomerular filtration rate (eGFR). We reviewed the predictive value of different eGFR equations in regard to frailty and disability outcomes. METHODS: We searched Pubmed from inception to March 2018 for studies investigating the association between eGFR and self-reported and/or objective measures of frailty or disability. Cross-sectional and longitudinal studies were separately analysed. RESULTS: We included 16 studies, one of which reporting both cross-sectional and longitudinal data. Three out of 7 cross-sectional studies compared different eGFR equations in regard to their association with functional status: two studies showed that cystatin C-based, but not creatinine-based eGFR may be associated with hand-grip strength or frailty; another study showed that two different creatinine-based eGFR equations may be similarly associated with disability. Four out of 10 longitudinal studies provided comparative data: two studies reported similar association with disability for different creatinine-based eGFR equations; one study showed that creatinine-based eGFR was not associated with frailty, but a not significant trend for association was observed with cystatin C-based eGFR; one study showed that cystatin C-based but not creatinine-based eGFR may predict incident mobility disability, while both methods may predict gait speed decline. High heterogeneity was observed in regard to confounders included in reviewed studies. None of them included the most recently published equations. CONCLUSION: Available data do not support the superiority of one of the eGFR equations in terms of measuring or predicting functional decline.
Authors: Kadjo Yves Cedric Adja; Jacopo Lenzi; Duygu Sezgin; Rónán O'Caoimh; Mara Morini; Gianfranco Damiani; Alessandra Buja; Maria Pia Fantini Journal: Front Public Health Date: 2020-11-12
Authors: George Smith; Alison Avenell; Margaret M Band; Geeta Hampson; Edmund J Lamb; Roberta C Littleford; Paul McNamee; Roy L Soiza; Deepa Sumukadas; Miles D Witham Journal: Eur Geriatr Med Date: 2021-03-17 Impact factor: 3.269
Authors: David R Lorenz; Shibani S Mukerji; Vikas Misra; Hajime Uno; Benjamin B Gelman; David J Moore; Elyse J Singer; Susan Morgello; Dana Gabuzda Journal: AIDS Date: 2021-12-01 Impact factor: 4.177
Authors: Agnieszka Guligowska; Andrea Corsonello; Małgorzata Pigłowska; Regina Roller-Wirnsberger; Gerhard Wirnsberger; Johan Ärnlöv; Axel C Carlsson; Lisanne Tap; Francesco Mattace-Raso; Francesc Formiga; Rafael Moreno-Gonzalez; Ellen Freiberger; Cornel Sieber; Pedro Gil Gregorio; Sara Laínez Martínez; Rada Artzi-Medvedik; Ilan Yehoshua; Paolo Fabbietti; Fabrizia Lattanzio; Tomasz Kostka Journal: BMC Geriatr Date: 2020-10-02 Impact factor: 3.921