Chloe Fletcher1, Carlene Wilson2, Amanda D Hutchinson3, Elizabeth Alice Grunfeld4. 1. Flinders Centre for Innovation in Cancer, College of Medicine and Public Health, Flinders University, GPO Box 2100, SA 5001, Australia. Electronic address: chloe.fletcher@flinders.edu.au. 2. Flinders Centre for Innovation in Cancer, College of Medicine and Public Health, Flinders University, GPO Box 2100, SA 5001, Australia; Olivia Newton John Cancer Wellness and Research Centre, 145 Studley Road, Heidelberg, VIC 3084, Australia; School of Psychology and Public Health, La Trobe University, Bundoora, VIC 3086, Australia. 3. School of Psychology, Social Work and Social Policy, University of South Australia, GPO Box 2471, SA 5001, Australia. 4. Department of Psychological Sciences, Birkbeck College, University of London, Mallet Street, London WC1E 7HX, UK.
Abstract
OBJECTIVE: To review the evidence for a systematic relationship between cancer patients' pre-treatment expectations (anticipated side effects) and subsequent experience of treatment-related side effects, and to compare this relationship in patients with no prior treatment experience (cognitive expectations) and with some prior treatment experience (conditioned response). METHODS: A total of 12,952 citations were identified through a comprehensive search of the literature published on or before November 2016 and screened against inclusion criteria. Studies were eligible if they included participants undergoing curative treatment for cancer, measured a treatment side effect, examined the relationship between anticipation and experience of side effects, and reported quantitative data. RESULTS: Thirty-one studies were included in the review and meta-analysis (total N = 5069). The side effects examined were nausea (anticipatory and post-treatment), vomiting, fatigue, pain, problems with concentration, and skin reactions. Meta-analyses indicated positive associations between anticipation and subsequent experience for all included side effects in patients with no prior treatment exposure (r = 0.153-0.431). Stronger associations were found for all included side effects in patients with previous treatment experience (r = 0.211-0.476), except for fatigue (r = 0.266) and pain (r = 0.235). No significant differences were found when overall effect sizes for patients with and without prior treatment exposure were compared for each side effect, except for anticipatory nausea (p = 0.012). CONCLUSION: These results may have implications for future interventions that target patients' expectations of cancer treatment-related side effects. Future research could explore patient reports of messages received about likely treatment effects both before and during treatment.
OBJECTIVE: To review the evidence for a systematic relationship between cancerpatients' pre-treatment expectations (anticipated side effects) and subsequent experience of treatment-related side effects, and to compare this relationship in patients with no prior treatment experience (cognitive expectations) and with some prior treatment experience (conditioned response). METHODS: A total of 12,952 citations were identified through a comprehensive search of the literature published on or before November 2016 and screened against inclusion criteria. Studies were eligible if they included participants undergoing curative treatment for cancer, measured a treatment side effect, examined the relationship between anticipation and experience of side effects, and reported quantitative data. RESULTS: Thirty-one studies were included in the review and meta-analysis (total N = 5069). The side effects examined were nausea (anticipatory and post-treatment), vomiting, fatigue, pain, problems with concentration, and skin reactions. Meta-analyses indicated positive associations between anticipation and subsequent experience for all included side effects in patients with no prior treatment exposure (r = 0.153-0.431). Stronger associations were found for all included side effects in patients with previous treatment experience (r = 0.211-0.476), except for fatigue (r = 0.266) and pain (r = 0.235). No significant differences were found when overall effect sizes for patients with and without prior treatment exposure were compared for each side effect, except for anticipatory nausea (p = 0.012). CONCLUSION: These results may have implications for future interventions that target patients' expectations of cancer treatment-related side effects. Future research could explore patient reports of messages received about likely treatment effects both before and during treatment.
Authors: Karin Meissner; Nicola Talsky; Elisabeth Olliges; Carmen Jacob; Oliver J Stötzer; Christoph Salat; Michael Braun; Raluca Flondor Journal: Front Pharmacol Date: 2019-04-25 Impact factor: 5.810
Authors: M C Meijers; J Stouthard; A W M Evers; E Das; H J Drooger; S J A J Jansen; A L Francke; N Plum; E van der Wall; Y Nestoriuc; E Dusseldorp; L M van Vliet Journal: Sci Rep Date: 2022-09-27 Impact factor: 4.996