Guillaume de Bonnecaze1, Benjamin Verillaud2, Leonor Chaltiel3, Sylvestre Fierens4, Mark Chapelier1, Cécile Rumeau5, Olivier Malard6, Marie Gavid7, Xavier Dufour8, Christian Righini9, Emmanuelle Uro-Coste10, Michel Rives11, Christine Bach12, Bertrand Baujat13, François Janot14, Ludovic de Gabory4, Sebastien Vergez1. 1. Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Rangueil-Larrey, Toulouse, France. 2. Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Lariboisière, Paris, France. 3. Biostatistics Department, L'Institut Universitaire du Cancer de Toulouse-Oncopole (IUCT-Oncopole), Cancer Institute, Toulouse, France. 4. Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Pellegrin, Bordeaux, France. 5. Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital of Nancy, Nancy, France. 6. Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Nantes, Nantes, France. 7. Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Saint-Etienne, Saint-Priest-en-Jarez, France. 8. Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Poitiers, Poitiers, France. 9. Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Grenoble, Grenoble, France. 10. Department of Pathology, IUCT-Oncopôle, Cancer Institute, Toulouse, France. 11. Radiation Oncology Department, IUCT-Oncopôle, Cancer Institute, Toulouse, France. 12. Department of Otorhinolaryngology-Head and Neck Surgery, Hopital Foch, Suresnes, France. 13. Department of Otorhinolaryngology-Head and Neck Surgery, Tenon Hospital, Paris-Est University, Paris, France. 14. Department of Otorhinolaryngology-Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France.
Abstract
BACKGROUND: Sinonasal undifferentiated carcinoma (SNUC) is a very rare entity with a poor prognosis. Due to the lack of studies on the subject, evidence is lacking concerning its management. METHODS: A multicenter collaborative study was conducted to assess treatment strategy, oncological outcome, and prognostic factors. RESULTS: Definitive analyses focused on 54 patients with a majority of advanced stage; the 3-year overall survival (OS) and 3-year recurrence-free survival (RFS) rates were, respectively, 62.4% and 47.8%. During the follow-up, 18 patients (33.3%) died, 10 (18.5%) developed metastases, 7 had lymph-node involvement (13%), and 12 (22.2%) showed recurrence or local progression. In univariate analyses, treatment modalities associated with improved RFS were induction chemotherapy (p = 0.02) and intensity-modulated radiotherapy (p = 0.007). In the multivariate analyses, only induction chemotherapy (p = 0.047, hazard ratio [HR] = 0.39) was significantly associated with improved RFS. CONCLUSION: Multimodal therapies including induction chemotherapy and intensity-modulated radiotherapy may improve the prognosis of SNUC; surgery might improve local control. Further multicenter studies are required.
BACKGROUND:Sinonasal undifferentiated carcinoma (SNUC) is a very rare entity with a poor prognosis. Due to the lack of studies on the subject, evidence is lacking concerning its management. METHODS: A multicenter collaborative study was conducted to assess treatment strategy, oncological outcome, and prognostic factors. RESULTS: Definitive analyses focused on 54 patients with a majority of advanced stage; the 3-year overall survival (OS) and 3-year recurrence-free survival (RFS) rates were, respectively, 62.4% and 47.8%. During the follow-up, 18 patients (33.3%) died, 10 (18.5%) developed metastases, 7 had lymph-node involvement (13%), and 12 (22.2%) showed recurrence or local progression. In univariate analyses, treatment modalities associated with improved RFS were induction chemotherapy (p = 0.02) and intensity-modulated radiotherapy (p = 0.007). In the multivariate analyses, only induction chemotherapy (p = 0.047, hazard ratio [HR] = 0.39) was significantly associated with improved RFS. CONCLUSION: Multimodal therapies including induction chemotherapy and intensity-modulated radiotherapy may improve the prognosis of SNUC; surgery might improve local control. Further multicenter studies are required.
Authors: Muhammad Faisal; Rudolf Seemann; Claudia Lill; Sasan Hamzavi; Arno Wutzl; Boban M Erovic; Stefan Janik Journal: Head Neck Date: 2020-01-10 Impact factor: 3.147
Authors: Valentina D A Corino; Marco Bologna; Giuseppina Calareso; Carlo Resteghini; Silvana Sdao; Ester Orlandi; Lisa Licitra; Luca Mainardi; Paolo Bossi Journal: J Imaging Date: 2022-02-15