Usman Abubakar1, Syed A S Sulaiman2. 1. Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Malaysia; Ibrahim Badamasi Babangida Specialist Hospital, Minna, Nigeria. Electronic address: pharmumma2@gmail.com. 2. Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Malaysia.
Abstract
BACKGROUND: Evidence to demonstrate the prevalence and trend of Methicillin Resistant Staphylococcus aureus (MRSA) infection in Nigeria is scarce. This review evaluates the prevalence, trend and antimicrobial susceptibility of clinical MRSA isolates reported in published studies. METHOD: Electronic search (PubMed, Scopus and Google scholar) was conducted using the following search terms: "MRSA OR Methicillin Resistant Staphylococcus aureus AND Nigeria." Reference list of selected studies was scanned to identify more studies. Studies published between 2007 and 2017 that tested at least 30 non-duplicate S. aureus isolates were selected. An independent reviewer extracted data from the studies using a standardized form. RESULTS: Twelve studies were included in this review. Overall, prevalence of MRSA infection increased from 18.3% (2009) to 42.3% (2013). The prevalence of MRSA infection was less than 50% in all the regions during the period under review. There was a decline in the prevalence of MRSA infection in the North-East (from 12.5% to 8.0%) between 2007 and 2012, and an increase in the South-West (from 20.2% to 47.4%) between 2006 and 2010. Wound, blood and urine specimens had the highest proportion of MRSA isolates. Non-susceptibility of MRSA strains to cotrimoxazole and tetracycline was greater than 85%. CONCLUSION: Prevalence of MRSA infection in Nigeria is rising, albeit regional variations. Non-susceptibility to commonly prescribed, orally available and inexpensive antibiotics was high. Antimicrobial resistance surveillance system, infection control, and antimicrobial stewardship interventions are recommended.
BACKGROUND: Evidence to demonstrate the prevalence and trend of Methicillin Resistant Staphylococcus aureus (MRSA) infection in Nigeria is scarce. This review evaluates the prevalence, trend and antimicrobial susceptibility of clinical MRSA isolates reported in published studies. METHOD: Electronic search (PubMed, Scopus and Google scholar) was conducted using the following search terms: "MRSA OR Methicillin Resistant Staphylococcus aureus AND Nigeria." Reference list of selected studies was scanned to identify more studies. Studies published between 2007 and 2017 that tested at least 30 non-duplicate S. aureus isolates were selected. An independent reviewer extracted data from the studies using a standardized form. RESULTS: Twelve studies were included in this review. Overall, prevalence of MRSA infection increased from 18.3% (2009) to 42.3% (2013). The prevalence of MRSA infection was less than 50% in all the regions during the period under review. There was a decline in the prevalence of MRSA infection in the North-East (from 12.5% to 8.0%) between 2007 and 2012, and an increase in the South-West (from 20.2% to 47.4%) between 2006 and 2010. Wound, blood and urine specimens had the highest proportion of MRSA isolates. Non-susceptibility of MRSA strains to cotrimoxazole and tetracycline was greater than 85%. CONCLUSION: Prevalence of MRSA infection in Nigeria is rising, albeit regional variations. Non-susceptibility to commonly prescribed, orally available and inexpensive antibiotics was high. Antimicrobial resistance surveillance system, infection control, and antimicrobial stewardship interventions are recommended.
Authors: Onyinye J Okorie-Kanu; Madubuike U Anyanwu; Ekene V Ezenduka; Anthony C Mgbeahuruike; Dipendra Thapaliya; Gracen Gerbig; Ejike E Ugwuijem; Christian O Okorie-Kanu; Philip Agbowo; Solomon Olorunleke; John A Nwanta; Kennedy F Chah; Tara C Smith Journal: PLoS One Date: 2020-05-14 Impact factor: 3.240
Authors: Eman E Abdeen; Walid S Mousa; Sarah Y Abdelsalam; Hanim S Heikal; Reyad R Shawish; Mohammed Nooruzzaman; Mohamed M Soliman; Gaber E Batiha; Ahmed Hamad; Ahmed Abdeen Journal: Antibiotics (Basel) Date: 2021-01-14
Authors: Lucas S C da Silva; Yasmin M F S Andrade; Arianne C Oliveira; Beatriz C Cunha; Eliana G Oliveira; Tamara S Cunha; Suzelle S Mafra; Jéssica B Almeida; Suzi P Carvalho; Flávia S Nascimento; Manoel Neres Santos Junior; Raiane C Chamon; Kátia R N Santos; Guilherme B Campos; Lucas M Marques Journal: Infect Prev Pract Date: 2020-08-23