Literature DB >> 29932916

BMP2/Smad signaling pathway is involved in the inhibition function of fibroblast growth factor 21 on vascular calcification.

Xiaoxiao Liu1, Fangying Cao2, Shuang Liu3, Yuhong Mi1, Jinghua Liu4.   

Abstract

Vascular calcification is extremely common and associated with major adverse cardiovascular events. Fibroblast growth factor (FGF) 21 has been identified as a potent metabolic regulator and a protector of the cardiovascular system. In this study, we aimed to investigate the effect of FGF21 on calcification of vascular smooth muscle cell (VSMC) and its mechanism. FGF21 inhibited beta-glycerophosphate (BGP) induced mineralization in VSMCs as determined by calcium concentration and Alizarin Red S. FGF21 suppressed BGP-induced BMP2/Smad signaling pathway components as well as osteoblast differentiation markers. FGF21 and Noggin could synergistically inhibit BGP-induced BMP2/Smad pathway expressions and calcification. Taken together, FGF21 inhibits vascular calcification in vitro by modulating BMP2/Smad signaling pathway.
Copyright © 2018. Published by Elsevier Inc.

Entities:  

Keywords:  BMP2/Smad signaling pathway; Fibroblast growth factor21; Noggin; Osteoblast differentiation; Vascular calcification

Mesh：

Substances：

Year:  2018        PMID： 29932916     DOI： 10.1016/j.bbrc.2018.06.098

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  4 in total

1.  FGF21, not GCN2, influences bone morphology due to dietary protein restrictions.

Authors:  Margaret A McNulty; Brad A Goupil; Diana C Albarado; Teresa Castaño-Martinez; Thomas H Ambrosi; Spela Puh; Tim J Schulz; Annette Schürmann; Christopher D Morrison; Thomas Laeger
Journal:  Bone Rep       Date:  2019-12-31

2.  Prevention of vascular calcification by the endogenous chromogranin A-derived mediator that inhibits osteogenic transdifferentiation.

Authors:  Setareh Orth-Alampour; Nathalie Gayrard; Silvia Salem; Àngel Argilés; Joachim Jankowski; Shruti Bhargava; Vera Jankowski; Bernard Jover; Cécile Notarnicola; Heidi Noels; Emiel P C van der Vorst; Christoph Kuppe; Michael Wolf; Claudia Goettsch; Wendy Theelen; Heike Bruck; Danilo Fliser; Joseph Loscalzo; Zhuojun Wu; Nikolaus Marx; Walter Zidek
Journal:  Basic Res Cardiol       Date:  2021-10-13       Impact factor: 17.165

Review 3.  Vascular Calcification-New Insights Into Its Mechanism.

Authors:  Sun Joo Lee; In-Kyu Lee; Jae-Han Jeon
Journal:  Int J Mol Sci       Date:  2020-04-13       Impact factor: 5.923

4.  MicroRNA-142 regulates osteoblast differentiation and apoptosis of mouse pre-osteoblast cells by targeting bone morphogenetic protein 2.

Authors:  Bing Luo; Jiafu Yang; Yi Yuan; Pandeng Hao; Xiaoyan Cheng
Journal:  FEBS Open Bio       Date:  2020-07-31       Impact factor: 2.693
  4 in total

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