| Literature DB >> 29932340 |
Yong Koy Bong1, Shiwei Song1, Jovana Nazor1,2, Michael Vogel1, Magnus Widegren1, Derek Smith1, Steven J Collier2, Rob Wilson1,2, S M Palanivel1, Karthik Narayanaswamy1, Ben Mijts2, Michael D Clay2, Ryan Fong2, Jeff Colbeck2, Amritha Appaswami2, Sheela Muley2, Jun Zhu2, Xiyun Zhang2, Jack Liang2, David Entwistle1,2.
Abstract
A wild-type Baeyer-Villiger monooxygenase was engineered to overcome numerous liabilities in order to mediate a commercial oxidation of pyrmetazole to esomeprazole, using air as the terminal oxidant in an almost exclusively aqueous reaction matrix. The developed enzyme and process compares favorably to the incumbent Kagan inspired chemocatalytic oxidation, as esomeprazole was isolated in 87% yield, in >99% purity, with an enantiomeric excess of >99%.Entities:
Year: 2018 PMID： 29932340 DOI： 10.1021/acs.joc.8b00468
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354