| Literature DB >> 29932025 |
Murat Bozdag1, Abdulmalik Saleh Alfawaz Altamimi2, Daniela Vullo1, Claudiu T Supuran1, Fabrizio Carta1.
Abstract
The current review is intended to highlight recent advances in the search of new and effective modulators of the metalloenzymes Carbonic Anhydrases (CAs, EC 4.2.1.1) expressed in humans (h). CAs reversibly catalyze the CO2 hydration reaction, which is of crucial importance in the regulation of a plethora of fundamental processes at cellular level as well as in complex organisms. The first section of this review will be dedicated to compounds acting as activators of the hCAs (CAAs) and their promising effects on central nervous system affecting pathologies mainly characterized from memory and learning impairments. The second part will focus on the emerging chemical classes acting as hCA inhibitors (CAIs) and their potential use for the treatment of diseases. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Entities:
Keywords: carbonic anhydrases; enzyme activators; enzyme inhibitors; glaucoma; metalloenzymes; reumathoid arthritis; tumors.
Mesh：
Substances：
Year: 2019 PMID： 29932025 DOI： 10.2174/0929867325666180622120625
Source DB: PubMed Journal: Curr Med Chem ISSN： 0929-8673 Impact factor: 4.530