Christopher J Burke1,2, William R Walter3, Sushma Gaddam3, Hien Pham4, James S Babb5, Joseph Sanger6, Fabio Ponzo6. 1. Department of Radiology, NYU Langone Orthopedic Hospital, 301 E 17th St, New York, NY, 10003, USA. christopher.burke@nyumc.org. 2. Department of Radiology, NYU Langone Orthopedic Hospital, New York, NY, USA. christopher.burke@nyumc.org. 3. Department of Radiology, NYU Langone Orthopedic Hospital, 301 E 17th St, New York, NY, 10003, USA. 4. Department of Orthopedic Surgery, NYU Hospital for Joint Diseases, Center for Musculoskeletal Care, 301 E 17th St, New York, NY, 10003, USA. 5. Department of Statistics, NYU Langone Medical Center, 660 1st Avenue, New York, NY, 10016, USA. 6. Department of Nuclear Medicine, NYU Langone Medical Center, 560 1st Avenue, New York, NY, 10016, USA.
Abstract
OBJECTIVES: To correlate patterns of 18F-FDG uptake on whole-body PET-CT with MR findings and compare the degree of FDG activity between symptomatic and asymptomatic knees. MATERIALS AND METHODS: Retrospective database query was performed using codes for knee MRI as well as whole-body PET-CT. Patients with malignant disease involving the knee or hardware were excluded. Patients who had both studies performed within 1 year between 2012 and 2017 were included for analysis. Knee joint osteoarthrosis, meniscal and ligamentous integrity, presence of joint effusion, and synovitis were assessed and recorded. Bone marrow edema lesions (BMELs) were identified, segmented, and analyzed using volumetric analysis. SUVmax was assessed over the suprapatellar joint space, intercondylar notch and Hoffa's fat pad. Symptomatic and asymptomatic knees were compared in patients with unilateral symptoms. RESULTS: Twenty-two cases (20 patients) with mean age 63.3 years (range, 36-91 years) were included. Two patients had bilateral pain. The most FDG avid regions in both symptomatic and asymptomatic knees were the intercondylar notch (SUVmax = 1.84 vs. 1.51), followed by suprapatellar pouch (SUVmax = 1.74 vs. 1.29) and Hoffa's fat pad (SUVmax = 1.01 vs. 0.87). SUVmax was significantly associated with cartilage loss (mean modified Outerbridge score) (r = 0.60, p = 0.003) and degree of synovitis (r = 0.48, p = 0023). Overall, mean SUVmax was significantly higher in the presence of a meniscal tear (1.83 ± 0.67 vs. 1.22 ± 0.40, p = 0.030). Nine patients had BMELs (volume: range = 0.6-27.8, mean = 7.79) however there was no significant association between BMEL volume and SUVmax. CONCLUSIONS: Higher FDG activity correlates with intra-articular derangement and the intercondylar notch represents the most metabolically active region of the knee.
OBJECTIVES: To correlate patterns of 18F-FDG uptake on whole-body PET-CT with MR findings and compare the degree of FDG activity between symptomatic and asymptomatic knees. MATERIALS AND METHODS: Retrospective database query was performed using codes for knee MRI as well as whole-body PET-CT. Patients with malignant disease involving the knee or hardware were excluded. Patients who had both studies performed within 1 year between 2012 and 2017 were included for analysis. Knee joint osteoarthrosis, meniscal and ligamentous integrity, presence of joint effusion, and synovitis were assessed and recorded. Bone marrow edema lesions (BMELs) were identified, segmented, and analyzed using volumetric analysis. SUVmax was assessed over the suprapatellar joint space, intercondylar notch and Hoffa's fat pad. Symptomatic and asymptomatic knees were compared in patients with unilateral symptoms. RESULTS: Twenty-two cases (20 patients) with mean age 63.3 years (range, 36-91 years) were included. Two patients had bilateral pain. The most FDG avid regions in both symptomatic and asymptomatic knees were the intercondylar notch (SUVmax = 1.84 vs. 1.51), followed by suprapatellar pouch (SUVmax = 1.74 vs. 1.29) and Hoffa's fat pad (SUVmax = 1.01 vs. 0.87). SUVmax was significantly associated with cartilage loss (mean modified Outerbridge score) (r = 0.60, p = 0.003) and degree of synovitis (r = 0.48, p = 0023). Overall, mean SUVmax was significantly higher in the presence of a meniscal tear (1.83 ± 0.67 vs. 1.22 ± 0.40, p = 0.030). Nine patients had BMELs (volume: range = 0.6-27.8, mean = 7.79) however there was no significant association between BMEL volume and SUVmax. CONCLUSIONS: Higher FDG activity correlates with intra-articular derangement and the intercondylar notch represents the most metabolically active region of the knee.
Authors: Katrin D M Stumpe; Jose Romero; Oliver Ziegler; Ehab M Kamel; Gustav K von Schulthess; Klaus Strobel; Juerg Hodler Journal: Eur J Nucl Med Mol Imaging Date: 2006-05-24 Impact factor: 9.236
Authors: David S Hersh; Jonathan Chun; Howard L Weiner; Steven Pulitzer; Henry Rusinek; Jonathan Roth; Orrin Devinsky; Sarah S Milla Journal: J Neurosurg Pediatr Date: 2013-05-10 Impact factor: 2.375
Authors: Anne Roivainen; Riitta Parkkola; Timo Yli-Kerttula; Pertti Lehikoinen; Tapio Viljanen; Timo Möttönen; Pirjo Nuutila; Heikki Minn Journal: Arthritis Rheum Date: 2003-11
Authors: Babak Saboury; Molly A Parsons; Mateen Moghbel; Domenico Rubello; Alex Brothers; Drew A Torigian; Thomas J Werner; Sina Houshmand; Sandip Basu; Marnix G E H Lam; Abass Alavi Journal: Nucl Med Commun Date: 2016-03 Impact factor: 1.690