Literature DB >> 29930162

A reversible carnitine palmitoyltransferase (CPT1) inhibitor offsets the proliferation of chronic lymphocytic leukemia cells.

Elena Gugiatti1, Claudya Tenca1, Silvia Ravera2, Marina Fabbi3, Fabio Ghiotto1,4, Andrea N Mazzarello5, Davide Bagnara1,5, Daniele Reverberi4, Daniela Zarcone1, Giovanna Cutrona4, Adalberto Ibatici6, Ermanno Ciccone1, Zbigniew Darzynkiewicz7, Franco Fais1,4, Silvia Bruno8.   

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Year:  2018        PMID： 29930162      PMCID： PMC6278982          DOI： 10.3324/haematol.2017.175414

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


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  15 in total

1.  Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias.

Authors:  Maria Rosaria Ricciardi; Simone Mirabilii; Matteo Allegretti; Roberto Licchetta; Anna Calarco; Maria Rosaria Torrisi; Robin Foà; Raffaella Nicolai; Gianfranco Peluso; Agostino Tafuri
Journal:  Blood       Date:  2015-08-14       Impact factor: 22.113

2.  The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways.

Authors:  Daniela de Totero; Raffaella Meazza; Matteo Capaia; Marina Fabbi; Bruno Azzarone; Enrico Balleari; Marco Gobbi; Giovanna Cutrona; Manlio Ferrarini; Silvano Ferrini
Journal:  Blood       Date:  2007-10-15       Impact factor: 22.113

3.  IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells.

Authors:  Maria Fernanda Pascutti; Margot Jak; Jacqueline M Tromp; Ingrid A M Derks; Ester B M Remmerswaal; Rachel Thijssen; Martijn H A van Attekum; Gregor G van Bochove; Dieuwertje M Luijks; Steven T Pals; René A W van Lier; Arnon P Kater; Marinus H J van Oers; Eric Eldering
Journal:  Blood       Date:  2013-09-06       Impact factor: 22.113

4.  A Selective Novel Peroxisome Proliferator-Activated Receptor (PPAR)-α Antagonist Induces Apoptosis and Inhibits Proliferation of CLL Cells In Vitro and In Vivo.

Authors:  Davorka Messmer; Kymmy Lorrain; Karin Stebbins; Yalda Bravo; Nicholas Stock; Geraldine Cabrera; Lucia Correa; Austin Chen; Jason Jacintho; Nicholas Chiorazzi; Xiao Jie Yan; David Spaner; Peppi Prasit; Daniel Lorrain
Journal:  Mol Med       Date:  2015-06-09       Impact factor: 6.354

5.  High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia.

Authors:  D Heintel; D Kienle; M Shehata; A Kröber; E Kroemer; I Schwarzinger; D Mitteregger; T Le; A Gleiss; C Mannhalter; A Chott; J Schwarzmeier; C Fonatsch; A Gaiger; H Döhner; S Stilgenbauer; U Jäger
Journal:  Leukemia       Date:  2005-07       Impact factor: 11.528

6.  Carnitine-acyltransferase system inhibition, cancer cell death, and prevention of myc-induced lymphomagenesis.

Authors:  Annalisa Pacilli; Maria Calienni; Sabrina Margarucci; Maria D'Apolito; Orsolina Petillo; Laura Rocchi; Gianandrea Pasquinelli; Raffaella Nicolai; Aleardo Koverech; Menotti Calvani; Gianfranco Peluso; Lorenzo Montanaro
Journal:  J Natl Cancer Inst       Date:  2013-03-13       Impact factor: 13.506

7.  The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells.

Authors:  Pablo G Longo; Luca Laurenti; Stefania Gobessi; Simona Sica; Giuseppe Leone; Dimitar G Efremov
Journal:  Blood       Date:  2007-10-10       Impact factor: 22.113

8.  Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction.

Authors:  Ismael Samudio; Romain Harmancey; Michael Fiegl; Hagop Kantarjian; Marina Konopleva; Borys Korchin; Kumar Kaluarachchi; William Bornmann; Seshagiri Duvvuri; Heinrich Taegtmeyer; Michael Andreeff
Journal:  J Clin Invest       Date:  2009-12-21       Impact factor: 14.808

9.  Selective reversible inhibition of liver carnitine palmitoyl-transferase 1 by teglicar reduces gluconeogenesis and improves glucose homeostasis.

Authors:  Roberto Conti; Edoardo Mannucci; Pompeo Pessotto; Emanuela Tassoni; Paolo Carminati; Fabio Giannessi; Arduino Arduini
Journal:  Diabetes       Date:  2011-02       Impact factor: 9.461

10.  STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia.

Authors:  Feng-Ting Liu; Li Jia; Ping Wang; Huaqing Wang; Timothy W Farren; Samir G Agrawal
Journal:  Oncotarget       Date:  2016-05-31
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  10 in total

Review 1.  The Role of Metabolic Plasticity in Blood and Brain Stem Cell Pathophysiology.

Authors:  Catherine J Libby; Jonathan McConathy; Victor Darley-Usmar; Anita B Hjelmeland
Journal:  Cancer Res       Date:  2019-10-01       Impact factor: 12.701

Review 2.  Targeting Energy Metabolism in Cancer Treatment.

Authors:  Joanna Kubik; Ewelina Humeniuk; Grzegorz Adamczuk; Barbara Madej-Czerwonka; Agnieszka Korga-Plewko
Journal:  Int J Mol Sci       Date:  2022-05-16       Impact factor: 6.208

3.  SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.

Authors:  Li Xiu Xu; Li Jun Hao; Jun Qi Ma; Jing Kun Liu; Ayshamgul Hasim
Journal:  Mol Cell Biochem       Date:  2019-11-01       Impact factor: 3.396

Review 4.  The role and therapeutic implication of CPTs in fatty acid oxidation and cancers progression.

Authors:  Junmin Wang; Hongjiao Xiang; Yifei Lu; Tao Wu; Guang Ji
Journal:  Am J Cancer Res       Date:  2021-06-15       Impact factor: 6.166

5.  Adipocytes Provide Fatty Acids to Acute Lymphoblastic Leukemia Cells.

Authors:  Jonathan Tucci; Ting Chen; Katherine Margulis; Etan Orgel; Rebecca L Paszkiewicz; Michael D Cohen; Matthew J Oberley; Rachel Wahhab; Anthony E Jones; Ajit S Divakaruni; Cheng-Chih Hsu; Sarah E Noll; Xia Sheng; Richard N Zare; Steven D Mittelman
Journal:  Front Oncol       Date:  2021-04-22       Impact factor: 6.244

Review 6.  Reprogramming of Fatty Acid Metabolism in Gynaecological Cancers: Is There a Role for Oestradiol?

Authors:  Azilleo Kristo Mozihim; Ivy Chung; Nur Akmarina B M Said; Amira Hajirah Abd Jamil
Journal:  Metabolites       Date:  2022-04-14

7.  Revealing potential lipid biomarkers in clear cell renal cell carcinoma using targeted quantitative lipidomics.

Authors:  Wen Li; Xiaobin Wang; Xianbin Zhang; Peng Gong; Degang Ding; Ning Wang; Zhifeng Wang
Journal:  Lipids Health Dis       Date:  2021-11-13       Impact factor: 3.876

Review 8.  The role of liver kinase B1 in tumor progression through regulation of lipid metabolism.

Authors:  Jialu Geng; Yanghe Zhang; Qingfei Meng; Hang Yan; Yishu Wang
Journal:  Clin Transl Oncol       Date:  2022-07-27       Impact factor: 3.340

9.  Levocarnitine does not impair chemotherapy cytotoxicity against acute lymphoblastic leukemia.

Authors:  Jessica L Sea; Etan Orgel; Ting Chen; Rebecca L Paszkiewicz; Abigail S Krall; Matthew J Oberley; Linsey Stiles; Steven D Mittelman
Journal:  Leuk Lymphoma       Date:  2019-09-16

10.  Berberine affects mitochondrial activity and cell growth of leukemic cells from chronic lymphocytic leukemia patients.

Authors:  Silvia Ravera; Fabio Ghiotto; Claudya Tenca; Elena Gugiatti; Sara Santamaria; Bernardetta Ledda; Adalberto Ibatici; Giovanna Cutrona; Andrea N Mazzarello; Davide Bagnara; Martina Cardillo; Daniela Zarcone; Zbigniew Darzynkiewicz; Ermanno Ciccone; Franco Fais; Silvia Bruno
Journal:  Sci Rep       Date:  2020-10-05       Impact factor: 4.379
  10 in total

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