| Literature DB >> 29930131 |
Eric Augier1, Estelle Barbier2, Russell S Dulman3, Valentina Licheri4, Gaëlle Augier2, Esi Domi2, Riccardo Barchiesi2, Sean Farris5, Daniel Nätt2, R Dayne Mayfield5, Louise Adermark4, Markus Heilig2.
Abstract
Alcohol addiction leads to increased choice of alcohol over healthy rewards. We established an exclusive choice procedure in which ~15% of outbred rats chose alcohol over a high-value reward. These animals displayed addiction-like traits, including high motivation to obtain alcohol and pursuit of this drug despite adverse consequences. Expression of the γ-aminobutyric acid (GABA) transporter GAT-3 was selectively decreased within the amygdala of alcohol-choosing rats, whereas a knockdown of this transcript reversed choice preference of rats that originally chose a sweet solution over alcohol. GAT-3 expression was selectively decreased in the central amygdala of alcohol-dependent people compared to those who died of unrelated causes. Impaired GABA clearance within the amygdala contributes to alcohol addiction, appears to translate between species, and may offer targets for new pharmacotherapies for treating this disorder.Entities:
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Year: 2018 PMID： 29930131 DOI： 10.1126/science.aao1157
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728