Literature DB >> 2992997

Increased myocardial alpha 1 adrenoceptor density in rats chronically treated with propranolol.

A Mügge, C Reupcke, H Scholz.   

Abstract

Chronic treatment with propranolol for 6 weeks resulted in a 16.6% increase, over the level in control rats, in myocardial alpha 1-adrenoceptor density as measured by [3H]prazosin binding. The apparent affinity remained unaffected. No changes were observed in beta-adrenoceptor density and apparent affinity as measured by [3H]dihydroalprenolol binding. It is concluded that myocardial alpha 1-adrenoceptors might have a compensatory role under conditions where beta-adrenergic effects are attenuated.

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Year:  1985        PMID： 2992997     DOI： 10.1016/0014-2999(85)90503-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

Review 1.  [Alpha-adrenoceptors in the myocardium: incidence and functional significance].

Authors:  A Mügge
Journal:  Klin Wochenschr       Date:  1985-11-04

2.  Pharmacokinetic and alpha 1-adrenoceptor antagonistic properties of two cyanine-type inhibitors of extraneuronal monoamine transport.

Authors:  H Russ; B Friedgen; B Königs; C Schumacher; K H Graefe; E Schömig
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996 Aug-Sep       Impact factor: 3.000

Review 3.  Beta receptor antagonists in the treatment of heart failure.

Authors:  H Persson; L Erhardt
Journal:  Cardiovasc Drugs Ther       Date:  1991-06       Impact factor: 3.727

4.  Effects of acute ischemia in the dog on myocardial blood flow, beta receptors, and adenylate cyclase activity with and without chronic beta blockade.

Authors:  J S Karliner; M B Stevens; N Honbo; J I Hoffman
Journal:  J Clin Invest       Date:  1989-02       Impact factor: 14.808

5.  Time course and extent of alpha 1-adrenoceptor density changes in rat heart after beta-adrenoceptor blockade.

Authors:  V Steinkraus; M Nose; H Scholz; K Thormählen
Journal:  Br J Pharmacol       Date:  1989-02       Impact factor: 8.739

6.  Potentiation of alpha-adrenoceptor-mediated responses following chronic beta-adrenoceptor stimulation in the rat heart.

Authors:  M C Butterfield; R Chess-Williams
Journal:  Br J Pharmacol       Date:  1993-03       Impact factor: 8.739

7.  Postsynaptic alpha-2 adrenergic receptors are critical for the antidepressant-like effects of desipramine on behavior.

Authors:  Han-Ting Zhang; Lisa R Whisler; Ying Huang; Yang Xiang; James M O'Donnell
Journal:  Neuropsychopharmacology       Date:  2008-10-15       Impact factor: 7.853

8.  Properties of cardiac alpha- and beta-adrenoceptors in spontaneously hypertensive rats.

Authors:  M Böhm; D Beuckelmann; F Diet; G Feiler; M J Lohse; E Erdmann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-10       Impact factor: 3.000
  8 in total

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