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Literature DB >> 29929421

Transcription infidelity and genome integrity: the parallax view.

Alasdair J E Gordon¹, Priya Sivaramakrishnan^1,2, Jennifer A Halliday¹, Christophe Herman^1,3,4.

Abstract

It was recently shown that removal of GreA, a transcription fidelity factor, enhances DNA break repair. This counterintuitive result, arising from unresolved backtracked RNA polymerase impeding DNA resection and thereby facilitating RecA-loading, leads to an interesting corollary: error-free full-length transcripts and broken chromosomes. Therefore, transcription fidelity may compromise genomic integrity.

Entities: Gene

Keywords: Backtracked RNA polymerase; DNA break repair; DNA resection; DksA; Epimutation; Genetic noise; Genomic integrity; GreAB; RecBCD; Transcription fidelity

Mesh：

Substances：

Year: 2018 PMID： 29929421 PMCID： PMC6150618 DOI： 10.1080/21541264.2018.1491251

Source DB: PubMed Journal: Transcription ISSN： 2154-1272

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References

34 in total

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Transcription infidelity and genome integrity: the parallax view.

1. Stochastic protein expression in individual cells at the single molecule level.

2. Transcription through the roadblocks: the role of RNA polymerase cooperation.

3. The transcription factor DksA prevents conflicts between DNA replication and transcription machinery.

4. UvrD facilitates DNA repair by pulling RNA polymerase backwards.

Review 5. Epigenetic switches: can infidelity govern fate in microbes?

6. Transcriptional arrest: Escherichia coli RNA polymerase translocates backward, leaving the 3' end of the RNA intact and extruded.

7. The RNA-DNA hybrid maintains the register of transcription by preventing backtracking of RNA polymerase.

8. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage.

9. Bacterial global regulators DksA/ppGpp increase fidelity of transcription.

10. The transcription fidelity factor GreA impedes DNA break repair.