Literature DB >> 29928908

Advancement in the treatment of haemophilia.

Rahul Bhardwaj1, Goutam Rath1, Amit K Goyal2.   

Abstract

Poor understanding of the pathophysiological mechanisms involved in Haemophilia is a major obstacle in accessing effective haemophilia disease management. Haemophilia is a life-frightening bleeding problem in which there are repeated bleeding episodes. Various approaches have been used, involves clotting factor replacement therapy for effective bleeding control in Haemophilia. Current advancements in the management of patients with haemophilia include altered pharmacokinetics clotting factor concentrates for better prophylaxis and management of haemophilia. This review sums up the prophylactic treatment, novel production techniques, other treatment techniques and the present position of gene therapy in the treatment of haemophilia.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Advancements in therapy; Factor VIII; Haemophilia

Mesh:

Year:  2018        PMID: 29928908     DOI: 10.1016/j.ijbiomac.2018.06.084

Source DB:  PubMed          Journal:  Int J Biol Macromol        ISSN: 0141-8130            Impact factor:   6.953


  3 in total

1.  FVIII expression by its native promoter sustains long-term correction avoiding immune response in hemophilic mice.

Authors:  Simone Merlin; Rosella Famà; Ester Borroni; Diego Zanolini; Valentina Bruscaggin; Silvia Zucchelli; Antonia Follenzi
Journal:  Blood Adv       Date:  2019-03-12

2.  Peritesticular scarring: An unusual presentation of hemophilia B.

Authors:  Mona Khoshkhesal; Alan C G Pham; Aniruddh V Deshpande
Journal:  Urol Ann       Date:  2022-04-18

3.  Rare but not Abdicated: Status of Haemophilia in foothills of Himalaya, Uttarakhand: A cross-sectional study.

Authors:  Vyas K Rathaur; N K V Vigneshwar; Ayesha Imran; Monika Pathania; Sonam Agrawal; Swathi Chacham; Prashant K Verma; Nowneet K Bhat
Journal:  J Family Med Prim Care       Date:  2021-04-08
  3 in total

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