Karen Champenois1,2, Rémonie Seng1,2,3, Anne Persoz1,2, Asma Essat1,2, Catherine Gaud4, Didier Laureillard5, Olivier Robineau6,7, Claudine Duvivier8,9, Yazdan Yazdanpanah10,11,12, Cécile Goujard1,2,13, Laurence Meyer1,2,3. 1. Inserm, CESP U1018, Le Kremlin-Bicêtre. 2. Université Paris Sud, Faculté de médecine, Le Kremlin-Bicêtre. 3. AP-HP, Epidémiologie et Santé publique, Hôpital Bicêtre, Le Kremlin-Bicêtre. 4. Service d'immunologie clinique, CHU Réunion Site Nord, Ile de la Réunion. 5. Service de maladies infectieuses et tropicales, CHU Caremeau, Nimes. 6. Service de maladies infectieuses et tropicales, Hôpital Gustave Dron, Tourcoing. 7. Université Lille 2, Faculté de Médecine, Lille. 8. Institut Pasteur, Centre Médical de l'Institut-Pasteur, Centre d'Infectiologie Necker-Pasteur. 9. Université Paris Descartes, Sorbonne Paris Cité, Equipe d'Accueil EA 7327. 10. INSERM, IAME, UMR 1137. 11. Université Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité. 12. AP-HP, Hôpital Bichat, Service de maladies infectieuses et tropicales, Paris. 13. AP-HP, Service de médecine interne, Hôpital Bicêtre, Le Kremlin Bicêtre, France.
Abstract
BACKGROUND: With the advent of treatment as prevention of HIV infection (TasP), we assessed trends in sexual behaviours between 2000 and 2017 among HIV-infected MSM enrolled in the French ANRS PRIMO cohort. METHODS: At each cohort visit, a clinical questionnaire including laboratory values was completed and a self-administered questionnaire was used to collect sexual behaviours, that is, the number, type (steady/casual) and HIV status (positive or negative/unknown) of partners, and condom use. The possible influence of viral load (undetectable/detectable) measured at the preceding visit on the evolution over time of sexual behaviour was assessed with logistic regression models fitted by generalized estimating equations (GEE), taking into account longitudinal data. RESULTS: We analyzed data from 10657 follow-up visits by 1364 MSM. Overall, whatever the considered behavioural variable: at least one sexual partner, steady and/or casual, condomless sex with steady, casual partners, serodiscordant or not, we observed a calendar increase with a particularly more marked rise from 2010 (P < 0.0001). Inconsistent condom use did not differ according to the viral load status (detectable vs. undetectable). Trends in inconsistent condom use increased across different generations of MSM, as defined by the year they were diagnosed with HIV infection. CONCLUSIONS: 'Having a sexual partner' and condomless sex, both increased in frequency between 2000 and 2017. Viral load status did not influence condom use as could have been expected from the 2008 Swiss Statement.
BACKGROUND: With the advent of treatment as prevention of HIV infection (TasP), we assessed trends in sexual behaviours between 2000 and 2017 among HIV-infected MSM enrolled in the French ANRS PRIMO cohort. METHODS: At each cohort visit, a clinical questionnaire including laboratory values was completed and a self-administered questionnaire was used to collect sexual behaviours, that is, the number, type (steady/casual) and HIV status (positive or negative/unknown) of partners, and condom use. The possible influence of viral load (undetectable/detectable) measured at the preceding visit on the evolution over time of sexual behaviour was assessed with logistic regression models fitted by generalized estimating equations (GEE), taking into account longitudinal data. RESULTS: We analyzed data from 10657 follow-up visits by 1364 MSM. Overall, whatever the considered behavioural variable: at least one sexual partner, steady and/or casual, condomless sex with steady, casual partners, serodiscordant or not, we observed a calendar increase with a particularly more marked rise from 2010 (P < 0.0001). Inconsistent condom use did not differ according to the viral load status (detectable vs. undetectable). Trends in inconsistent condom use increased across different generations of MSM, as defined by the year they were diagnosed with HIV infection. CONCLUSIONS: 'Having a sexual partner' and condomless sex, both increased in frequency between 2000 and 2017. Viral load status did not influence condom use as could have been expected from the 2008 Swiss Statement.
Authors: Fiona C Lampe; Alison J Rodger; William Burman; Andrew Grulich; Gerald Friedland; Wafaa El Sadr; James Neaton; Giulio M Corbelli; Sean Emery; Jean Michel Molina; Chloe Orkin; Jose Gatell; Jan Gerstoft; Kiat Ruxrungtham; Monica Barbosa de Souza; Andrew N Phillips Journal: AIDS Date: 2019-12-01 Impact factor: 4.177
Authors: Maartje G J Basten; Daphne A van Wees; Amy Matser; Anders Boyd; Ganna Rozhnova; Chantal den Daas; Mirjam E E Kretzschmar; Janneke C M Heijne Journal: PLoS One Date: 2021-12-09 Impact factor: 3.240