Literature DB >> 2992762

The PLC/PRF/5 human hepatoma cell line. II. Chromosomal assignment of hepatitis B virus integration sites.

A M Bowcock, M R Pinto, E Bey, J M Kuyl, G M Dusheiko, R Bernstein.   

Abstract

The chromosomal sites at which hepatitis B virus (HBV) DNA is integrated into the genome of the hepatocellular carcinoma (HCC) cell line, PLC/PRF/5 were investigated in an attempt to understand the mechanisms by which hepatitis B virus may induce malignant transformation. In situ hybridization of an HBV DNA probe to metaphase chromosomes of the PLC/PRF/5 cell line, followed by statistical analysis, identified three integration sites; these were 15q22-q23, 11q22, and 18q12. In particular, hybridization to chromosome #15, which is present in four copies in complete metaphases of this cell line, was highly significant (p much less than 0.0005).

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Year:  1985        PMID： 2992762     DOI： 10.1016/0165-4608(85)90034-2

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  7 in total

1.  Expression and biosynthetic variation of the epidermal growth factor receptor in human hepatocellular carcinoma-derived cell lines.

Authors:  C R Carlin; D Simon; J Mattison; B B Knowles
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

2.  Chromosomal sites for hepatitis B virus integration in human hepatocellular carcinoma.

Authors:  T Tokino; K Matsubara
Journal:  J Virol       Date:  1991-12       Impact factor: 5.103

3.  HBV genome-enriched single cell sequencing revealed heterogeneity in HBV-driven hepatocellular carcinoma (HCC).

Authors:  Wenhui Wang; Yan Chen; Liang Wu; Yi Zhang; Seungyeul Yoo; Quan Chen; Shiping Liu; Yong Hou; Xiao-Ping Chen; Qian Chen; Jun Zhu
Journal:  BMC Med Genomics       Date:  2022-06-16       Impact factor: 3.622

Review 4.  Hepatitis B virus infection and primary hepatocellular carcinoma.

Authors:  M Feitelson
Journal:  Clin Microbiol Rev       Date:  1992-07       Impact factor: 26.132

5.  Viral integration, fragile sites, and proto-oncogenes in human neoplasia.

Authors:  N C Popescu; D Zimonjic; J A DiPaolo
Journal:  Hum Genet       Date:  1990-04       Impact factor: 4.132

6.  Analysis of HBV Genomes Integrated into the Genomes of Human Hepatoma PLC/PRF/5 Cells by HBV Sequence Capture-Based Next-Generation Sequencing.

Authors:  Tomotaka Ishii; Akinori Tamura; Toshikatsu Shibata; Kazumichi Kuroda; Tatsuo Kanda; Masaya Sugiyama; Masashi Mizokami; Mitsuhiko Moriyama
Journal:  Genes (Basel)       Date:  2020-06-18       Impact factor: 4.096

Review 7.  Cellular Genomic Sites of Hepatitis B Virus DNA Integration.

Authors:  Magdalena A Budzinska; Nicholas A Shackel; Stephan Urban; Thomas Tu
Journal:  Genes (Basel)       Date:  2018-07-20       Impact factor: 4.096
  7 in total

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