Literature DB >> 2992693

Evidence for impaired GABAergic activity in the substantia nigra of amygdaloid kindled rats.

W Löscher, W S Schwark.   

Abstract

The activity of the GABA-synthesizing enzyme glutamate decarboxylase (GAD) was determined in synaptosomal fractions from 12 brain regions of amygdaloid kindled rats. The only significant difference in regional GAD activities between kindled animals and sham-operated controls was a 40% decrease of GAD activity in the substantia nigra. The data suggest that impaired GABAergic function in the nigra may be involved in the initiation and propagation of amygdaloid-kindled seizures.

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Year:  1985        PMID： 2992693     DOI： 10.1016/0006-8993(85)90634-1

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  10 in total

Review 1.  The role of the brain stem in generalized epileptic seizures.

Authors:  C L Faingold
Journal:  Metab Brain Dis       Date:  1987-06       Impact factor: 3.584

Review 2.  A review of evidence for GABergic predominance/glutamatergic deficit as a common etiological factor in both schizophrenia and affective psychoses: more support for a continuum hypothesis of "functional" psychosis.

Authors:  R F Squires; E Saederup
Journal:  Neurochem Res       Date:  1991-10       Impact factor: 3.996

3.  Alterations of GABA metabolism and seizure susceptibility in the substantia nigra of the kindled rat acclimating to changes in osmotic state.

Authors:  C F Baxter; C C Oh; C G Wasterlain; L K Ozaki; R A Baldwin
Journal:  Neurochem Res       Date:  1991-03       Impact factor: 3.996

4.  High doses of memantine (1-amino-3,5-dimethyladamantane) induce seizures in kindled but not in non-kindled rats.

Authors:  W Löscher; D Hönack
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-05       Impact factor: 3.000

5.  Decrease in number of hippocampal gamma-aminobutyric acid (GABA) immunoreactive cells in the rat kindling model of epilepsy.

Authors:  W Kamphuis; W J Wadman; R M Buijs; F H Lopes da Silva
Journal:  Exp Brain Res       Date:  1986       Impact factor: 1.972

6.  Damage of substantia nigra pars reticulata during pilocarpine-induced status epilepticus in the rat: immunohistochemical study of neurons, astrocytes and serum-protein extravasation.

Authors:  R Schmidt-Kastner; C Heim; K H Sontag
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

7.  Decrease in GABA immunoreactivity and alteration of GABA metabolism after kindling in the rat hippocampus.

Authors:  W Kamphuis; E Huisman; W J Wadman; F H Lopes da Silva
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

8.  Benefits and risks of intranigral transplantation of GABA-producing cells subsequent to the establishment of kindling-induced seizures.

Authors:  Marc W Nolte; Wolfgang Löscher; Christiane Herden; William J Freed; Manuela Gernert
Journal:  Neurobiol Dis       Date:  2008-07-15       Impact factor: 5.996

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Journal:  Annu Rev Nutr       Date:  2007       Impact factor: 11.848

Review 10.  Bypassing the Blood-Brain Barrier: Direct Intracranial Drug Delivery in Epilepsies.

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Journal:  Pharmaceutics       Date:  2020-11-24       Impact factor: 6.321
  10 in total

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