Literature DB >> 2992657

The effect of nedocromil sodium and sodium cromoglycate on antigen-induced bronchoconstriction in the Ascaris-sensitive monkey.

R P Eady, B Greenwood, D M Jackson, T S Orr, E Wells.   

Abstract

Nedocromil sodium inhibited the bronchoconstriction caused by antigen challenge in Ascaris-sensitive monkeys and in addition it prevented the release of histamine from mast cells lavaged from sensitive monkeys. Sodium cromoglycate was relatively inactive in both these systems. It is suggested that nedocromil sodium can stabilize both mucosal and connective tissue mast cells and may represent a new type of drug.

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Year:  1985        PMID： 2992657      PMCID： PMC1916590          DOI： 10.1111/j.1476-5381.1985.tb08864.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

1.  Mast cells in rat gastrointestinal mucosa. I. Effects of fixation.

Authors:  L Enerbäck
Journal:  Acta Pathol Microbiol Scand       Date:  1966

2.  Biological techniques for studying the allergenic components of nematodes. I. Detection of allergenic components in Ascaris suum extracts.

Authors:  J Ambler; J E Doe; D K Gemmell; J A Roberts; T S Orr
Journal:  J Immunol Methods       Date:  1972-08       Impact factor: 2.303

3.  Modification of the enzymatic isotopic assay of histamine and its application to measurement of histamine in tissues, serum and urine.

Authors:  M A Beaven; S Jacobsen; Z Horáková
Journal:  Clin Chim Acta       Date:  1972-03       Impact factor: 3.786

4.  The effects of pentobarbitone and chloralose anaesthesia on the vagal component of bronchoconstriction produced by histamine aerosol in the anaesthetized dog.

Authors:  D M Jackson; I M Richards
Journal:  Br J Pharmacol       Date:  1977-10       Impact factor: 8.739

5.  Mucosal mast cells of the rat intestine: a re-evaluation of fixation and staining properties, with special reference to protein blocking and solubility of the granular glycosaminoglycan.

Authors:  U Wingren; L Enerbäck
Journal:  Histochem J       Date:  1983-06

6.  Laboratory infection of primates with Ascaris suum to provide a model of allergic bronchoconstriction.

Authors:  D I Pritchard; R P Eady; S T Harper; D M Jackson; T S Orr; I M Richards; S Trigg; E Wells
Journal:  Clin Exp Immunol       Date:  1983-11       Impact factor: 4.330

7.  Nedocromil sodium: a new drug for the management of bronchial asthma.

Authors:  S Lal; S Malhotra; D Gribben; D Hodder
Journal:  Thorax       Date:  1984-11       Impact factor: 9.139

8.  Ascaris-induced bronchoconstriction in primates experimentally infected with Ascaris suum ova.

Authors:  I M Richards; R P Eady; D M Jackson; T S Orr; D I Pritchard; K Vendy; E Wells
Journal:  Clin Exp Immunol       Date:  1983-11       Impact factor: 4.330
  8 in total
  18 in total

1.  Effect of nedocromil sodium on sulphur dioxide induced bronchoconstriction.

Authors:  C M Dixon; R W Fuller; P J Barnes
Journal:  Thorax       Date:  1987-06       Impact factor: 9.139

Review 2.  Nedocromil sodium. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of reversible obstructive airways disease.

Authors:  J P Gonzalez; R N Brogden
Journal:  Drugs       Date:  1987-11       Impact factor: 9.546

3.  The pharmacokinetics of nedocromil sodium, a new drug for the treatment of reversible obstructive airways disease, in human volunteers and patients with reversible obstructive airways disease.

Authors:  M G Neale; K Brown; R A Foulds; S Lal; D A Morris; D Thomas
Journal:  Br J Clin Pharmacol       Date:  1987-10       Impact factor: 4.335

4.  Development of preclinical models for testing antiasthma drugs.

Authors:  T S Orr
Journal:  Drugs       Date:  1989       Impact factor: 9.546

5.  Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human lung mast cells.

Authors:  K B Leung; K C Flint; J Brostoff; B N Hudspith; N M Johnson; H Y Lau; W L Liu; F L Pearce
Journal:  Thorax       Date:  1988-10       Impact factor: 9.139

Review 6.  Respiratory and allergic disease. I.

Authors:  K F Chung; P J Barnes
Journal:  Br Med J (Clin Res Ed)       Date:  1988-01-02

7.  Early use of inhaled nedocromil sodium in children following an acute episode of asthma.

Authors:  A M Edwards; J Lyons; E Weinberg; F Weinberg; J D Gillies; G Reid; C F Robertson; P Robinson; M Dalton; P Van Asperen; C Wilson; J Mullineux; A Mullineux; P D Sly; M Cox; A F Isles
Journal:  Thorax       Date:  1999-04       Impact factor: 9.139

Review 8.  Nedocromil sodium. An updated review of its pharmacological properties and therapeutic efficacy in asthma.

Authors:  R N Brogden; E M Sorkin
Journal:  Drugs       Date:  1993-05       Impact factor: 9.546

9.  Involvement of inflammatory mediators in the airway responses to trimellitic anhydride in sensitized guinea-pigs.

Authors:  J P Hayes; J O Lotvall; P J Barnes; A J Newman Taylor; K F Chung
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739

10.  Nedocromil sodium inhibits airway hyperresponsiveness and eosinophilic infiltration induced by repeated antigen challenge in guinea-pigs.

Authors:  R R Schellenberg; K Ishida; R J Thomson
Journal:  Br J Pharmacol       Date:  1991-08       Impact factor: 8.739
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