Alyssa Huff1,2,3, Mitchell D Reed2,3, Barbara K Smith4, Edward H Brown2,3, Alexander V Ovechkin1,2,3, Teresa Pitts5,6,7. 1. Department of Physiology, University of Louisville, Louisville, KY, USA. 2. Department of Neurological Surgery, University of Louisville, Louisville, KY, USA. 3. Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA. 4. Department of Physical Therapy, University of Florida, Gainesville, FL, USA. 5. Department of Neurological Surgery, University of Louisville, Louisville, KY, USA. t.pitts@louisville.edu. 6. Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA. t.pitts@louisville.edu. 7. Department of Neurological Surgery, Kentucky Spinal Cord Injury Research Center, School of Medicine, University of Louisville, 511 S Floyd Street, Louisville, KY, 40202, USA. t.pitts@louisville.edu.
Abstract
PURPOSE: Airway protective behaviors, like cough and swallow, deteriorate in many populations suffering from neurologic disorders. While coordination of these behaviors has been investigated in an animal model, it has not been tested in humans. METHODS: We used a novel protocol, adapted from previous work in the cat, to assess cough and swallow independently and their coordination strategies in seven healthy males (26 ± 6 years). Surface electromyograms of the submental complex and external oblique complex, spirometry, and thoracic and abdominal wall kinematics, were used to evaluate the timing of swallow, cough, and breathing as well as lung volume (LV) during these behaviors. RESULTS: Unlike the cat, there was significant variability in the cough-swallow phase preference; however, there was a targeted LV range in which swallow occurred. CONCLUSION: These results give insight into the differences between the cat and human models in airway protective strategies related to the coordination of cough and swallow behaviors, allowing for better understanding of dystussia and dysphagia.
PURPOSE: Airway protective behaviors, like cough and swallow, deteriorate in many populations suffering from neurologic disorders. While coordination of these behaviors has been investigated in an animal model, it has not been tested in humans. METHODS: We used a novel protocol, adapted from previous work in the cat, to assess cough and swallow independently and their coordination strategies in seven healthy males (26 ± 6 years). Surface electromyograms of the submental complex and external oblique complex, spirometry, and thoracic and abdominal wall kinematics, were used to evaluate the timing of swallow, cough, and breathing as well as lung volume (LV) during these behaviors. RESULTS: Unlike the cat, there was significant variability in the cough-swallow phase preference; however, there was a targeted LV range in which swallow occurred. CONCLUSION: These results give insight into the differences between the cat and human models in airway protective strategies related to the coordination of cough and swallow behaviors, allowing for better understanding of dystussia and dysphagia.
Authors: D H McFarland; B Martin-Harris; A-J Fortin; K Humphries; E Hill; K Armeson Journal: Respir Physiol Neurobiol Date: 2016-09-06 Impact factor: 1.931
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Authors: Donald C Bolser; Christian Gestreau; Kendall F Morris; Paul W Davenport; Teresa E Pitts Journal: Otolaryngol Clin North Am Date: 2013-10-18 Impact factor: 3.346
Authors: Teresa Pitts; Albright G Gayagoy; Melanie J Rose; Ivan Poliacek; Jillian A Condrey; M Nicholas Musselwhite; Tabitha Y Shen; Paul W Davenport; Donald C Bolser Journal: PLoS One Date: 2015-05-28 Impact factor: 3.240
Authors: Teresa Pitts; Kimberly E Iceman; Alyssa Huff; M Nicholas Musselwhite; Michael L Frazure; Kellyanna C Young; Clinton L Greene; Dena R Howland Journal: J Neurophysiol Date: 2022-07-13 Impact factor: 2.974