Literature DB >> 29925265

The Structural Enzymology of Iterative Aromatic Polyketide Synthases: A Critical Comparison with Fatty Acid Synthases.

Shiou-Chuan (Sheryl) Tsai1.   

Abstract

Polyketides are a large family of structurally complex natural products including compounds with important bioactivities. Polyketides are biosynthesized by polyketide synthases (PKSs), multienzyme complexes derived evolutionarily from fatty acid synthases (FASs). The focus of this review is to critically compare the properties of FASs with iterative aromatic PKSs, including type II PKSs and fungal type I nonreducing PKSs whose chemical logic is distinct from that of modular PKSs. This review focuses on structural and enzymological studies that reveal both similarities and striking differences between FASs and aromatic PKSs. The potential application of FAS and aromatic PKS structures for bioengineering future drugs and biofuels is highlighted.

Entities:  

Keywords:  directed biosynthesis; enzymology; fatty acid synthase; natural products; polyketide synthase; structural biology

Mesh：

Substances：

Year:  2018        PMID： 29925265     DOI： 10.1146/annurev-biochem-063011-164509

Source DB:  PubMed          Journal:  Annu Rev Biochem        ISSN： 0066-4154            Impact factor:   23.643


  10 in total

1.  Computational structural enzymology methodologies for the study and engineering of fatty acid synthases, polyketide synthases and nonribosomal peptide synthetases.

Authors:  Andrew J Schaub; Gabriel O Moreno; Shiji Zhao; Hau V Truong; Ray Luo; Shiou-Chuan Tsai
Journal:  Methods Enzymol       Date:  2019-04-22       Impact factor: 1.600

2.  Biocontrol potential and antifungal mechanism of a novel Streptomyces sichuanensis against Fusarium oxysporum f. sp. cubense tropical race 4 in vitro and in vivo.

Authors:  Dengfeng Qi; Liangping Zou; Dengbo Zhou; Miaoyi Zhang; Yongzan Wei; Kai Li; Yankun Zhao; Lu Zhang; Jianghui Xie
Journal:  Appl Microbiol Biotechnol       Date:  2022-02-10       Impact factor: 4.813

Review 3.  Fatty Acid Synthase: Structure, Function, and Regulation.

Authors:  Aybeg N Günenc; Benjamin Graf; Holger Stark; Ashwin Chari
Journal:  Subcell Biochem       Date:  2022

4.  Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis.

Authors:  Cécile Bon; Stéphanie Cabantous; Sylviane Julien; Valérie Guillet; Christian Chalut; Julie Rima; Yoann Brison; Wladimir Malaga; Angelique Sanchez-Dafun; Sabine Gavalda; Annaïk Quémard; Julien Marcoux; Geoffrey S Waldo; Christophe Guilhot; Lionel Mourey
Journal:  BMC Biol       Date:  2022-06-21       Impact factor: 7.364

5.  Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases.

Authors:  Chen Wang; Xiaojing Wang; Liwen Zhang; Qun Yue; Qingpei Liu; Ya-Ming Xu; A A Leslie Gunatilaka; Xiaoyi Wei; Yuquan Xu; István Molnár
Journal:  J Am Chem Soc       Date:  2020-09-23       Impact factor: 15.419

Review 6.  Diversity, Ecology, and Prevalence of Antimicrobials in Nature.

Authors:  Megan M Mullis; Ian M Rambo; Brett J Baker; Brandi Kiel Reese
Journal:  Front Microbiol       Date:  2019-11-14       Impact factor: 5.640

7.  Molecular Basis for Polyketide Ketoreductase-Substrate Interactions.

Authors:  Shiji Zhao; Fanglue Ni; Tianyin Qiu; Jacob T Wolff; Shiou-Chuan Tsai; Ray Luo
Journal:  Int J Mol Sci       Date:  2020-10-13       Impact factor: 5.923

8.  Formicamycin biosynthesis involves a unique reductive ring contraction.

Authors:  Zhiwei Qin; Rebecca Devine; Thomas J Booth; Elliot H E Farrar; Matthew N Grayson; Matthew I Hutchings; Barrie Wilkinson
Journal:  Chem Sci       Date:  2020-06-16       Impact factor: 9.969

Review 9.  Probing the structure and function of acyl carrier proteins to unlock the strategic redesign of type II polyketide biosynthetic pathways.

Authors:  Ariana Sulpizio; Callie E W Crawford; Rebecca S Koweek; Louise K Charkoudian
Journal:  J Biol Chem       Date:  2021-01-23       Impact factor: 5.157

10.  Structural comparison of Acinetobacter baumannii β-ketoacyl-acyl carrier protein reductases in fatty acid and aryl polyene biosynthesis.

Authors:  Woo Cheol Lee; Sungjae Choi; Ahjin Jang; Kkabi Son; Yangmee Kim
Journal:  Sci Rep       Date:  2021-04-12       Impact factor: 4.379
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.