Literature DB >> 2992488

The presence of two mitochondrial DNA topoisomerases in human acute leukemia cells.

F J Castora, G M Lazarus, D Kunes.   

Abstract

We have undertaken a study of DNA topoisomerases in mitochondria from human acute leukemia cells. Two activities have been detected in these organelles. One of the enzymes is presumably a type II topoisomerase, i.e., in ATP-dependent reactions it can catenate closed circular plasmid DNA, and decatenate closed circular kinetoplast DNA. A second topoisomerase is presumably a type I enzyme since, it can relax positive as well as negative supercoils in an ATP-independent reaction, it is unable to catenate plasmid DNA or decatenate kinetoplast DNA, and it is inhibited, rather than stimulated, by ATP.

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Year:  1985        PMID： 2992488     DOI： 10.1016/0006-291x(85)90495-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Localization of a DNA topoisomerase II to mitochondria inDictyostelium discoideum: Deletion mutant analysis and mitochondrial targeting signal presequence.

Authors:  K Komori; F Maruo; T Morio; H Urushihara; Y Tanaka
Journal:  J Plant Res       Date:  1997-03       Impact factor: 2.629

2.  Human mitochondrial topoisomerase I.

Authors:  H Zhang; J M Barceló; B Lee; G Kohlhagen; D B Zimonjic; N C Popescu; Y Pommier
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-28       Impact factor: 11.205

3.  ATP inhibits nuclear and mitochondrial type I topoisomerases from human leukemia cells.

Authors:  F J Castora; W G Kelly
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

4.  Quinolones and coumarins eliminate chloroplasts from Euglena gracilis.

Authors:  J Krajcovic; L Ebringer; J Polónyi
Journal:  Antimicrob Agents Chemother       Date:  1989-11       Impact factor: 5.191

5.  Energy-dependent mitochondrial mutagenicity of antibacterial ofloxacin and its recombinogenic activity in yeast.

Authors:  M Obernauerová; J Subík
Journal:  Curr Genet       Date:  1994-09       Impact factor: 3.886

6.  Ofloxacin induces cytoplasmic respiration-deficient mutants in yeast Saccharomyces cerevisiae.

Authors:  M Obernauerová; J Subík; L Ebringer
Journal:  Curr Genet       Date:  1992-05       Impact factor: 3.886

Review 7.  Controlling the topology of mammalian mitochondrial DNA.

Authors:  Katja E Menger; Alejandro Rodríguez-Luis; James Chapman; Thomas J Nicholls
Journal:  Open Biol       Date:  2021-09-22       Impact factor: 6.411

8.  Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria.

Authors:  Hongliang Zhang; Yong-Wei Zhang; Takehiro Yasukawa; Ilaria Dalla Rosa; Salim Khiati; Yves Pommier
Journal:  Nucleic Acids Res       Date:  2014-05-06       Impact factor: 16.971
  8 in total

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