Literature DB >> 29924725

The function of sphingomyelinases in mycobacterial infections.

Yuqing Wu1, Erich Gulbins1,2, Heike Grassmé1.   

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the deadliest and most important infectious diseases worldwide. The sphingomyelinase/ceramide system, which has been shown several times to be a crucial factor in the internalization, processing and killing of diverse pathogens, also modulates the pro-inflammatory response and the state of mycobacteria in macrophages. Both acid and neutral sphingomyelinases are important in this activity. However, studies of the role of sphingomyelinases in TB are still at an early stage.

Entities:  

Keywords:  Mycobacterium bovis; acid sphingomyelinase (Asm); bacillus Calmette-Guérin (BCG); ceramide; granuloma; mycobacteria; neutral sphingomyelinase (Nsm); sphingomyelin; tuberculosis (TB)

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Year:  2018        PMID： 29924725     DOI： 10.1515/hsz-2018-0179

Source DB:  PubMed          Journal:  Biol Chem        ISSN： 1431-6730            Impact factor:   3.915


  4 in total

1.  Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens.

Authors:  Chelsea L Cockburn; Ryan S Green; Sheela R Damle; Rebecca K Martin; Naomi N Ghahrai; Punsiri M Colonne; Marissa S Fullerton; Daniel H Conrad; Charles E Chalfant; Daniel E Voth; Elizabeth A Rucks; Stacey D Gilk; Jason A Carlyon
Journal:  Life Sci Alliance       Date:  2019-03-22

2.  Sphingomyelin Biosynthesis Is Essential for Phagocytic Signaling during Mycobacterium tuberculosis Host Cell Entry.

Authors:  Patrick Niekamp; Gaelen Guzman; Hans C Leier; Ali Rashidfarrokhi; Veronica Richina; Fabian Pott; Caroline Barisch; Joost C M Holthuis; Fikadu G Tafesse
Journal:  mBio       Date:  2021-01-26       Impact factor: 7.867

3.  Novel Potential Diagnostic Serum Biomarkers of Metabolomics in Osteoarticular Tuberculosis Patients: A Preliminary Study.

Authors:  Ximeng Chen; Jingyun Ye; Hong Lei; Chengbin Wang
Journal:  Front Cell Infect Microbiol       Date:  2022-03-25       Impact factor: 5.293

Review 4.  Glycosphingolipids and Infection. Potential New Therapeutic Avenues.

Authors:  Johannes M F G Aerts; M Artola; M van Eijk; M J Ferraz; R G Boot
Journal:  Front Cell Dev Biol       Date:  2019-12-06
  4 in total

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