Literature DB >> 2992415

Parathion-provoked lethality in rats is reduced by diethyldithiocarbamate.

J Homann, S Schneider, K J Matthes.   

Abstract

Intoxication of male rats with 5 mg/kg parathion reduces survival to 15%. Diethyldithiocarbamate (DDC), known to inhibit mixed-function oxidase activity, has no effect on survival rate when this compound is used in a dosage of 300 mg/kg 45 min before or 10 min after parathion intoxication. However, when DDC and parathion are administered simultaneously, the rate of survival rises to 53%.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2992415     DOI： 10.1007/bf00343127

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  11 in total

1.  Activation of thionophosphates by liver microsomes.

Authors:  R D O'BRIEN
Journal:  Nature       Date:  1959-01-10       Impact factor: 49.962

2.  A cholinesterase inhibitor derived from OO-diethyl O-p-nitrophenyl thiophosphate in vivo.

Authors:  J C GAGE
Journal:  Biochem J       Date:  1953-06       Impact factor: 3.857

3.  Studies on the mechanism of phenobarbital-induced protection against parathion in adult female rats.

Authors:  J G Alary; J Brodeur
Journal:  J Pharmacol Exp Ther       Date:  1969-10       Impact factor: 4.030

4.  Protection by diethyldithiocarbamate against carbon tetrachloride lethality in rats and against carbon tetrachloride-induced lipid peroxidation in vitro.

Authors:  L M Lutz; E A Glende; R O Recknagel
Journal:  Biochem Pharmacol       Date:  1973-07-15       Impact factor: 5.858

5.  Protective effect of diethyldithiocarbamate and carbon disulfide against liver injury induced by various hepatotoxic agents.

Authors:  Y Masuda; N Nakayama
Journal:  Biochem Pharmacol       Date:  1982-09-01       Impact factor: 5.858

6.  Studies of the enzymic mechanism of the metabolism of diethyl 4-nitrophenyl phosphorothionate (parathion) by rat liver microsomes.

Authors:  R A Neal
Journal:  Biochem J       Date:  1967-10       Impact factor: 3.857

7.  Serum esterases. II. An enzyme hydrolysing diethyl p-nitrophenyl phosphate (E600) and its identity with the A-esterase of mammalian sera.

Authors:  W N ALDRIDGE
Journal:  Biochem J       Date:  1953-01       Impact factor: 3.857

8.  Studies on the metabolism of diethyl 4-nitrophenyl phosphorothionate (parathion) in vitro.

Authors:  R A Neal
Journal:  Biochem J       Date:  1967-04       Impact factor: 3.857

9.  The effects of chlordane, DDT, and 3-methylcholanthrene upon the metabolism and toxicity of diethyl-4-nitrophenyl phosphorothionate (parathion).

Authors:  S K Chapman; K C Leibman
Journal:  Toxicol Appl Pharmacol       Date:  1971-04       Impact factor: 4.219

10.  Modifications of drug metabolism by disulfiram and diethyldithiocarbamate. I. Mixed-function oxygenase.

Authors:  M Lang; M Marselos; R Törrönen
Journal:  Chem Biol Interact       Date:  1976-11       Impact factor: 5.192
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.