Henna Salman1, Mohsin Shah2, Asif Ali3, Asma Aziz1, Salvatore Giovanni Vitale4. 1. Department of Physiology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan. 2. Department of Physiology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan. mohsin.ibms@kmu.edu.pk. 3. Department of Pathology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan. 4. Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy. vitalesalvatore@hotmail.com.
Abstract
INTRODUCTION: Pre-eclampsia is a pregnancy-induced disorder that complicates approximately 5-7% of pregnancies. It is the leading cause of maternal and foetal morbidity and mortality worldwide. AIM: To determine the role of serum neurokinin-B level in the pathophysiology of pre-eclampsia. METHODS: This was a case-control study. A total of 80 pregnant women in their third trimester of pregnancy were included in the study. They were divided into two groups (40 pre-eclamptic and 40 normotensive) according to the presence or absence of clinical parameters of pre-eclampsia. Serum level of neurokinin-B was measured with ELISA. RESULTS: Maternal age, weight, BMI, pulse, systolic BP and diastolic BP were statistically higher in the pre-eclampsia group compared to the normotensive group (P < 0.0001). Moreover, statistically higher levels were observed for neurokinin-B in the normotensive group as compared to the pre-eclamptic group. The mean value of neurokinin-B was 83.50 ng/L in the pre-eclamptic group compared to 111.5 ng/L in the normotensive group (P = 0.006). CONCLUSION: Higher levels of serum neurokinin-B were observed in the normotensive pregnant females as compared to the pre-eclamptic females. Thus, apparently, it seems that serum neurokinin-B plays no role in the pathophysiology of pre-eclampsia, and further large multicentre prospective studies may be required to ascertain its role.
INTRODUCTION:Pre-eclampsia is a pregnancy-induced disorder that complicates approximately 5-7% of pregnancies. It is the leading cause of maternal and foetal morbidity and mortality worldwide. AIM: To determine the role of serum neurokinin-B level in the pathophysiology of pre-eclampsia. METHODS: This was a case-control study. A total of 80 pregnant women in their third trimester of pregnancy were included in the study. They were divided into two groups (40 pre-eclamptic and 40 normotensive) according to the presence or absence of clinical parameters of pre-eclampsia. Serum level of neurokinin-B was measured with ELISA. RESULTS: Maternal age, weight, BMI, pulse, systolic BP and diastolic BP were statistically higher in the pre-eclampsia group compared to the normotensive group (P < 0.0001). Moreover, statistically higher levels were observed for neurokinin-B in the normotensive group as compared to the pre-eclamptic group. The mean value of neurokinin-B was 83.50 ng/L in the pre-eclamptic group compared to 111.5 ng/L in the normotensive group (P = 0.006). CONCLUSION: Higher levels of serum neurokinin-B were observed in the normotensive pregnant females as compared to the pre-eclamptic females. Thus, apparently, it seems that serum neurokinin-B plays no role in the pathophysiology of pre-eclampsia, and further large multicentre prospective studies may be required to ascertain its role.
Authors: Gemma Biviá-Roig; Valentina Lucia La Rosa; María Gómez-Tébar; Lola Serrano-Raya; Juan José Amer-Cuenca; Salvatore Caruso; Elena Commodari; Antonio Barrasa-Shaw; Juan Francisco Lisón Journal: Int J Environ Res Public Health Date: 2020-08-15 Impact factor: 3.390