Meryem Ozlem Kutuk1, Ali Evren Tufan2, Gulen Guler3, Osman Ozgur Yalin4, Ebru Altintas5, Harika Gozukara Bag6, Derya Uluduz7, Fevziye Toros8, Nurgul Aytan9, Ozgur Kutuk10, Aynur Ozge11. 1. Department of Child and Adolescent Psychiatry, Baskent University, School of Medicine, Adana, Turkey; Department of Child and Adolescent Psychiatry, Abant Izzet Baysal University, School of Medicine, Bolu, Turkey. Electronic address: drozlemina@gmail.com. 2. Department of Child and Adolescent Psychiatry, Baskent University, School of Medicine, Adana, Turkey; Department of Child and Adolescent Psychiatry, Abant Izzet Baysal University, School of Medicine, Bolu, Turkey. 3. Department of Child and Adolescent Psychiatry, Elazig Mental Health Hospital, Elazig, Turkey. 4. Department of Neurology, Istanbul Training and Research Hospital, İstanbul, Turkey. 5. Department of Psychiatry, Baskent University, School of Medicine, Adana, Turkey. 6. Department of Biostatistics, Inonu University, School of Medicine, Malatya, Turkey. 7. Department of Neurology, Istanbul University, Cerrahpasa Faculty of Medicine, Istanbul, Turkey. 8. Department of Child and Adolescent Psychiatry, Mersin University, School of Medicine, Mersin, Turkey. 9. Department of Neurology, Boston University School of Medicine, Boston, USA. 10. Baskent University School of Medicine, Department of Medical Genetics, Adana Dr. Turgut Noyan Medical and Research Center, Adana, Turkey. 11. Department of Neurology, Mersin University, School of Medicine, Mersin, Turkey.
Abstract
OBJECTIVE: Attention deficit and hyperactivity disorder (ADHD) is a neuro-developmental disorder related to internalizing and externalizing disorders as well as somatic complaints and disorders. This study was conducted to evaluate the prevalence of headache subtypes, epilepsy, atopic disorders, motion sickness and recurrent abdominal pain among children and adolescents with ADHD and their parents. METHODS: In a multi-center, cross-sectional, familial association study using case-control design, treatment naïve children and adolescents between 6 and 18 years of age diagnosed with ADHD according to the DSM-5 criteria as well as age- and gender-matched healthy controls and their parents were evaluated by a neurologist and analyzed accordingly. RESULTS: 117 children and adolescents with ADHD and 111 controls were included. Headache disorder diagnosis was common for both patients and healthy controls (59.0% vs. 37.8%), with a significantly elevated rate in the ADHD group (p = 0.002). Migraine was found in 26.0% of ADHD patients and 9.9% of healthy controls. Tension headache was found in 32.4% of ADHD patients and 27.9% of healthy controls. Headache diagnosis was also found to be significantly more common in mothers of children with ADHD than control group mothers (90.5% vs. 36.6%, p < 0.001). CONCLUSION: Headache diagnoses and specifically migraines were significantly more common among children with ADHD and their mothers, while recurrent abdominal pain was elevated in both parents and ADHD patients. Migraine is an important part of ADHD comorbidity, not only for children but also for mothers. Motion sickness may be reduced among families of ADHD probands.
OBJECTIVE:Attention deficit and hyperactivity disorder (ADHD) is a neuro-developmental disorder related to internalizing and externalizing disorders as well as somatic complaints and disorders. This study was conducted to evaluate the prevalence of headache subtypes, epilepsy, atopic disorders, motion sickness and recurrent abdominal pain among children and adolescents with ADHD and their parents. METHODS: In a multi-center, cross-sectional, familial association study using case-control design, treatment naïve children and adolescents between 6 and 18 years of age diagnosed with ADHD according to the DSM-5 criteria as well as age- and gender-matched healthy controls and their parents were evaluated by a neurologist and analyzed accordingly. RESULTS: 117 children and adolescents with ADHD and 111 controls were included. Headache disorder diagnosis was common for both patients and healthy controls (59.0% vs. 37.8%), with a significantly elevated rate in the ADHD group (p = 0.002). Migraine was found in 26.0% of ADHDpatients and 9.9% of healthy controls. Tension headache was found in 32.4% of ADHDpatients and 27.9% of healthy controls. Headache diagnosis was also found to be significantly more common in mothers of children with ADHD than control group mothers (90.5% vs. 36.6%, p < 0.001). CONCLUSION:Headache diagnoses and specifically migraines were significantly more common among children with ADHD and their mothers, while recurrent abdominal pain was elevated in both parents and ADHDpatients. Migraine is an important part of ADHD comorbidity, not only for children but also for mothers. Motion sickness may be reduced among families of ADHD probands.
Authors: Pei-Yin Pan; Ulf Jonsson; Sabriye Selin Şahpazoğlu Çakmak; Alexander Häge; Sarah Hohmann; Hjalmar Nobel Norrman; Jan K Buitelaar; Tobias Banaschewski; Samuele Cortese; David Coghill; Sven Bölte Journal: Psychol Med Date: 2021-10-12 Impact factor: 7.723