Karolina Rak1, Danuta Kornafel2, Dominika Mazurek1, Monika Bronkowska1. 1. Department of Human Nutrition, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, Wrocław, Poland. 2. Department of General Psychology, Faculty of Pedagogical Sciences, University of Lower Silesia, Wrocław, Poland.
Abstract
Objective: To investigate the relation between level of antibodies against lactoferrin (LfAb) in maternal serum (MS) and birth anthropometry of healthy full-term newborns. Methods: The study included 105 pairs of mother-newborn. MS LfAb level was determined using ELISA kit. Spearman's correlation and Kruskal-Wallis one-way analysis of variance (ANOVA) were applied to establish the relationship between MS LfAb level and birth weight (BW), birth weight-to-birth length ratio (BW/BL), and head circumference (HC) of newborns. Results: The U-shaped relation of MS LfAb and BW was demonstrated (p = .019). Negative correlation between MS LfAb and BW/BL was observed (p = .016). The most optimal birth weight and body proportion were observed in newborns of mothers with MS LfAb level of 49 ± 4 U/ml.Conclusions: Significant relationship between MS LfAb and birth anthropometry suggests serum Lf of pregnant women can be considered as a promising indirect biomarker of intrauterine homeostasis, verifiable noninvasively already during pregnancy and thus allowing predict, or even prevent, potential short- and long-term postnatal health consequences.
Objective: To investigate the relation between level of antibodies against lactoferrin (LfAb) in maternal serum (MS) and birth anthropometry of healthy full-term newborns. Methods: The study included 105 pairs of mother-newborn. MS LfAb level was determined using ELISA kit. Spearman's correlation and Kruskal-Wallis one-way analysis of variance (ANOVA) were applied to establish the relationship between MS LfAb level and birth weight (BW), birth weight-to-birth length ratio (BW/BL), and head circumference (HC) of newborns. Results: The U-shaped relation of MS LfAb and BW was demonstrated (p = .019). Negative correlation between MS LfAb and BW/BL was observed (p = .016). The most optimal birth weight and body proportion were observed in newborns of mothers with MS LfAb level of 49 ± 4 U/ml.Conclusions: Significant relationship between MS LfAb and birth anthropometry suggests serum Lf of pregnant women can be considered as a promising indirect biomarker of intrauterine homeostasis, verifiable noninvasively already during pregnancy and thus allowing predict, or even prevent, potential short- and long-term postnatal health consequences.
Entities:
Keywords:
Birth weight; body proportion; fetal development; inflammation in pregnancy; lactoferrin antibodies