Ana Laura Tellechea1, Victoria Luppo2, María Alejandra Morales2, Boris Groisman1, Agustin Baricalla2, Cintia Fabbri2, Anabel Sinchi2, Alicia Alonso3, Cecilia Gonzalez3, Bibiana Ledesma3, Patricia Masi4, María Silva4, Adriana Israilev5, Marcela Rocha6, Marcela Quaglia7, María Paz Bidondo1, Rosa Liascovich1, Pablo Barbero1. 1. National Network of Congenital Abnormalities Argentina (RENAC) under the National Center of Medical Genetics (CENAGEM), Buenos Aires City, Argentina. 2. National Institute of Human Viral Diseases "Dr. Julio I. Maiztegui" (INEVH), Pergamino, Buenos Aires, Argentina. 3. National Institute of Infectious Diseases "Dr. Carlos Malbrán" (INEI), Buenos Aires City, Argentina. 4. Neonatology Service, Dalmacio Velez Sarsfield Hospital, Ciudad Autónoma de Buenos Aires, Argentina. 5. Neonatology Service, Teodoro Alvarez Hospital, Ciudad Autónoma de Buenos Aires, Argentina. 6. Department of Neonatology, Instituto de Maternidad y Ginecología Nuestra Señora de las Mercedes, San Miguel de Tucumán, Argentina. 7. Neonatology Service, Materno Neonatal Hospital, Córdoba Capital, Córdoba, Argentina.
Abstract
BACKGROUND: Zika virus (ZIKV) vertical transmission may lead to microcephaly and other congenital anomalies. In March and April 2016, the first outbreak of ZIKV occurred in Argentina. The objective was to describe the surveillance of newborns with microcephaly and other selected brain anomalies in Argentina, and evaluation different etiologies. METHODS: Participants were enrolled between April 2016 and March 2017. CASES: newborns from the National Network of Congenital Abnormalities of Argentina (RENAC) with head circumference lower than the 3rd percentile according to gestational age and sex, or selected brain anomalies. Blood and urine samples from cases and their mothers were tested for ZIKV by real-time polymerase chain reaction (RT-PCR), antigen-specific Immunoglobulin M (MAC-ELISA) and plaque-reduction neutralization test (PRNT90 ). Toxoplasmosis, rubella, herpes simplex, syphilis, and cytomegalovirus (CMV) infection were also tested. RESULTS: A total of 104 cases were reported, with a prevalence of 6.9 per 10,000 [95% confidence interval (CI): 5.7-8.4], a significant increase when compared with the data prior to 2016, Prevalence Rate Ratio 1.7 (95% CI 1.2-2.3). In five cases positive serology for ZIKV (IgM and IgG by PRNT) was detected. The five cases presented microcephaly with craniofacial disproportion. We detected four cases of CMV infection, three cases of congenital toxoplasmosis, two cases of herpes simplex infection, and one case of congenital syphilis. CONCLUSION: The prevalence of microcephaly was significantly higher when compared with the previous period. The system had the capacity to detect five cases with congenital ZIKV syndrome in a country with limited viral circulation.
BACKGROUND:Zika virus (ZIKV) vertical transmission may lead to microcephaly and other congenital anomalies. In March and April 2016, the first outbreak of ZIKV occurred in Argentina. The objective was to describe the surveillance of newborns with microcephaly and other selected brain anomalies in Argentina, and evaluation different etiologies. METHODS:Participants were enrolled between April 2016 and March 2017. CASES: newborns from the National Network of Congenital Abnormalities of Argentina (RENAC) with head circumference lower than the 3rd percentile according to gestational age and sex, or selected brain anomalies. Blood and urine samples from cases and their mothers were tested for ZIKV by real-time polymerase chain reaction (RT-PCR), antigen-specific Immunoglobulin M (MAC-ELISA) and plaque-reduction neutralization test (PRNT90 ). Toxoplasmosis, rubella, herpes simplex, syphilis, and cytomegalovirus (CMV) infection were also tested. RESULTS: A total of 104 cases were reported, with a prevalence of 6.9 per 10,000 [95% confidence interval (CI): 5.7-8.4], a significant increase when compared with the data prior to 2016, Prevalence Rate Ratio 1.7 (95% CI 1.2-2.3). In five cases positive serology for ZIKV (IgM and IgG by PRNT) was detected. The five cases presented microcephaly with craniofacial disproportion. We detected four cases of CMV infection, three cases of congenital toxoplasmosis, two cases of herpes simplex infection, and one case of congenital syphilis. CONCLUSION: The prevalence of microcephaly was significantly higher when compared with the previous period. The system had the capacity to detect five cases with congenital ZIKV syndrome in a country with limited viral circulation.
Authors: Mariah M Kalmin; Emily W Gower; Elizabeth M Stringer; Natalie M Bowman; Elizabeth T Rogawski McQuade; Daniel Westreich Journal: Paediatr Perinat Epidemiol Date: 2019-07 Impact factor: 3.980
Authors: Melisa Berenice Bonica; Silvina Goenaga; María Laura Martin; Mariel Feroci; Victoria Luppo; Evangelina Muttis; Cintia Fabbri; María Alejandra Morales; Delia Enria; María Victoria Micieli; Silvana Levis Journal: PLoS Negl Trop Dis Date: 2019-06-12