Lena Klingspor1, Måns Ullberg1,2, Johan Rydberg3, Nahid Kondori4, Lena Serrander5, Jonas Swanberg6, Kenneth Nilsson7, Cecilia Jendle Bengtén8, Marcus Johansson9, Margareta Granlund10, Eva Törnqvist11, Anders Nyberg12, Karin Kindlund13, Minna Ygge14, Dalila Kartout-Boukdir15, Michael Toepfer16, Eva Hålldin17, Gunnar Kahlmeter18, Volkan Özenci1,2. 1. Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden. 2. Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden. 3. Division of Laboratory Medicine, Department of Clinical Microbiology, Lund, Sweden. 4. Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 5. Department Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. 6. Department of Clinical Microbiology, Ryhov Hospital, Jönköping, Sweden. 7. Department of Medical Sciences, Section of Clinical Microbiology and Infectious Diseases, Uppsala University, Uppsala, Sweden. 8. Department of Clinical Microbiology, Karlstad Central Hospital, Karlstad, Sweden. 9. Department of Clinical Microbiology, Kalmar County Hospital, Kalmar, Sweden. 10. Department of Clinical Microbiology, Umeå University, Umeå, Sweden. 11. Department of Laboratory Medicine/Clinical Microbiology, Örebro University Hospital, Örebro, Sweden. 12. Laboratory Medicine/Clinical Microbiology, County Hospital Sundsvall-Härnösand, Sundsvall-Härnösand, Sweden. 13. Department of Clinical Microbiology, Hallands Hospital, Halmstad, Sweden. 14. Sunderby Hospital, Luleå, Sweden. 15. Unilabs AB, Clinical Microbiology, Mälarsjukhuset Hospital, Eskilstuna, Sweden. 16. Unilabs AB, Clinical Microbiology, Skaraborg Hospital, Skövde, Sweden. 17. Clinical Microbiology, Västerås Hospital, Västerås, Sweden. 18. Department of Clinical Microbiology, Central Hospital, Växjö, Sweden.
Abstract
OBJECTIVES: To identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates to identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates in Sweden. METHODS: The study was a retrospective, observational nationwide laboratory-based surveillance for fungaemia and fungal meningitis and was conducted from September 2015 to August 2016. RESULTS: In total, 488 Candida blood culture isolates were obtained from 471 patients (58% males). Compared to our previous study, the incidence of candidaemia has increased from 4.2/100 000 (2005-2006) to 4.7/100 000 population/year (2015-2016). The three most common Candida spp. isolated from blood cultures were Candida albicans (54.7%), Candida glabrata (19.7%) and species in the Candida parapsilosis complex (9.4%). Candida resistance to fluconazole was 2% in C. albicans and between 0% and 100%, in non-albicans species other than C. glabrata and C. krusei. Resistance to voriconazole was rare, except for C. glabrata, C. krusei and C. tropicalis. Resistance to anidulafungin was 3.8% while no Candida isolate was resistant to amphotericin B. CONCLUSIONS: We report an overall increase in candidaemia but a minor decrease of C. albicans while C. glabrata and C. parapsilosis remain constant over this 10-year period.
OBJECTIVES: To identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates to identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates in Sweden. METHODS: The study was a retrospective, observational nationwide laboratory-based surveillance for fungaemia and fungal meningitis and was conducted from September 2015 to August 2016. RESULTS: In total, 488 Candida blood culture isolates were obtained from 471 patients (58% males). Compared to our previous study, the incidence of candidaemia has increased from 4.2/100 000 (2005-2006) to 4.7/100 000 population/year (2015-2016). The three most common Candida spp. isolated from blood cultures were Candida albicans (54.7%), Candida glabrata (19.7%) and species in the Candida parapsilosis complex (9.4%). Candida resistance to fluconazole was 2% in C. albicans and between 0% and 100%, in non-albicans species other than C. glabrata and C. krusei. Resistance to voriconazole was rare, except for C. glabrata, C. krusei and C. tropicalis. Resistance to anidulafungin was 3.8% while no Candida isolate was resistant to amphotericin B. CONCLUSIONS: We report an overall increase in candidaemia but a minor decrease of C. albicans while C. glabrata and C. parapsilosis remain constant over this 10-year period.
Authors: Kai-Manuel Adam; Michael Osthoff; Frédéric Lamoth; Anna Conen; Véronique Erard; Katia Boggian; Peter W Schreiber; Stefan Zimmerli; Pierre-Yves Bochud; Dionysios Neofytos; Mapi Fleury; Hans Fankhauser; Daniel Goldenberger; Konrad Mühlethaler; Arnaud Riat; Reinhard Zbinden; Andreas Kronenberg; Chantal Quiblier; Oscar Marchetti; Nina Khanna Journal: Open Forum Infect Dis Date: 2021-09-17 Impact factor: 3.835