Paula Tâmara Vieira Teixeira Pereira1, Andréa Dias Reis2, Renata Rodrigues Diniz3, Franciléia Andrade Lima4, Richard Diego Leite5, Mayara Cristina Pinto da Silva6, Rosane Nassar Meireles Guerra6, Érica Brandão de Moraes Vieira7, João Batista Santos Garcia8. 1. Post-graduate Program in Adult Health, Federal University of Maranhão, Rua Munim n 1, Quadra 4, Bloco 10, apto 104, Condomínio Vitré, Recanto Vinhais, São Luís, MA, CEP 65070-017, Brazil. paulateixeiranutri@outlook.com. 2. Post-graduation Program in Movement Sciences of São Paulo State University, Rua Roberto Simonsen, 305, Centro Educacional, Presidente Prudente, SP, CEP 19060-900, Brazil. 3. Department of Physical Education of Federal University of Maranhão, Av. dos Portugueses, 1966 - Vila Bacanga, São Luís, MA, CEP 65065-545, Brazil. 4. Post-graduate Program in Adult Health, Federal University of Maranhão, Av. dos Portugueses, 1966 - Vila Bacanga, São Luís, MA, CEP 65065-545, Brazil. 5. Post-graduate Program in Physical Education, Federal University of Espírito Santo, Av. Fernando Ferrari, 514 - Goiabeiras, Vitória, ES, CEP 29075-910, Brazil. 6. Laboratory of Immunophysiology, Federal University of Maranhão, Av. dos Portugueses, 1966 - Vila Bacanga, São Luís, MA, CEP 65065-545, Brazil. 7. Municipal Health Secretary, Av. dos Franceses, 78 - Alemanha, São Luís, MA, CEP 65036-280, Brazil. 8. Academic Discipline of Anesthesiology, Pain and Palliative Care of Federal University of Maranhão, Av. dos Portugueses, 1966 - Vila Bacanga, São Luís, MA, 65065-545, Brazil.
Abstract
PURPOSE: Cancer-related fatigue (CRF) is defined as a distressing, persistent, and subjective sense of physical or emotional and/or cognitive exhaustion. The treatment of CRF includes pharmacological and non-pharmacological therapies; dietary strategies with promising results have also been used. This study aimed to identify dietary supplements that improve fatigue in patients with breast cancer. METHODS: A systematic review of the literature was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Data were obtained from PubMed, Scopus, MEDLINE, CENTRAL, and CINAHL databases using the following MeSH terms: breast neoplasms, dietary supplements, diet, and fatigue. In addition, the Google and Google Scholar search engines were used to find grey literature. Methodological quality was evaluated using the risk of bias in randomised clinical trials in the systematic Cochrane reviews, and the quality of the evidence was also analysed using the GRADE system. RESULTS: A total of 893 studies were assessed, of which eight were included in the review, with 932 women diagnosed with breast cancer. The most commonly used supplements that improve fatigue were guarana, acetyl-L-carnitine, and co-enzyme Q10. Two studies had a low risk of bias in all categories and three had high-quality evidence. CONCLUSIONS: Dietary supplements or diet patterns are seldom used to treat fatigue in patients with breast cancer. The results of this review showed that guarana extract and a diet rich in whole foods, omega-3 fatty acids, fruits, and vegetables could be used to treat CRF in patients with breast cancer. The studies had a low risk of bias with high-quality evidence on the efficacy of the interventions in treating fatigue in the study population.
PURPOSE:Cancer-related fatigue (CRF) is defined as a distressing, persistent, and subjective sense of physical or emotional and/or cognitive exhaustion. The treatment of CRF includes pharmacological and non-pharmacological therapies; dietary strategies with promising results have also been used. This study aimed to identify dietary supplements that improve fatigue in patients with breast cancer. METHODS: A systematic review of the literature was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Data were obtained from PubMed, Scopus, MEDLINE, CENTRAL, and CINAHL databases using the following MeSH terms: breast neoplasms, dietary supplements, diet, and fatigue. In addition, the Google and Google Scholar search engines were used to find grey literature. Methodological quality was evaluated using the risk of bias in randomised clinical trials in the systematic Cochrane reviews, and the quality of the evidence was also analysed using the GRADE system. RESULTS: A total of 893 studies were assessed, of which eight were included in the review, with 932 women diagnosed with breast cancer. The most commonly used supplements that improve fatigue were guarana, acetyl-L-carnitine, and co-enzyme Q10. Two studies had a low risk of bias in all categories and three had high-quality evidence. CONCLUSIONS: Dietary supplements or diet patterns are seldom used to treat fatigue in patients with breast cancer. The results of this review showed that guarana extract and a diet rich in whole foods, omega-3 fatty acids, fruits, and vegetables could be used to treat CRF in patients with breast cancer. The studies had a low risk of bias with high-quality evidence on the efficacy of the interventions in treating fatigue in the study population.
Entities:
Keywords:
Adverse effects; Breast neoplasms; Diet; Dietary supplement; Fatigue
Authors: Daise Pereira de Araujo; Paula Tâmara Vieira Teixeira Pereira; Ariadina Jansen Campos Fontes; Karla Danielle Silva Marques; Érica Brandão de Moraes; Rosane Nassar Meireles Guerra; João Batista Santos Garcia Journal: Support Care Cancer Date: 2021-06-19 Impact factor: 3.603
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