| Literature DB >> 29915430 |
Lang Wu1, Wei Shi2, Jirong Long1, Xingyi Guo1, Kyriaki Michailidou3,4, Jonathan Beesley2, Manjeet K Bolla3, Xiao-Ou Shu1, Yingchang Lu1, Qiuyin Cai1, Fares Al-Ejeh2, Esdy Rozali2, Qin Wang3, Joe Dennis3, Bingshan Li5, Chenjie Zeng1, Helian Feng6,7, Alexander Gusev8,9,10, Richard T Barfield6, Irene L Andrulis11,12, Hoda Anton-Culver13, Volker Arndt14, Kristan J Aronson15, Paul L Auer16,17, Myrto Barrdahl18, Caroline Baynes19, Matthias W Beckmann20, Javier Benitez21,22, Marina Bermisheva23,24, Carl Blomqvist25,26, Natalia V Bogdanova24,27,28, Stig E Bojesen29,30,31, Hiltrud Brauch32,33,34, Hermann Brenner14,34,35, Louise Brinton36, Per Broberg37, Sara Y Brucker38, Barbara Burwinkel39,40, Trinidad Caldés41, Federico Canzian42, Brian D Carter43, J Esteban Castelao44, Jenny Chang-Claude18,45, Xiaoqing Chen2, Ting-Yuan David Cheng46, Hans Christiansen27, Christine L Clarke47, Margriet Collée48, Sten Cornelissen49, Fergus J Couch50, David Cox51,52, Angela Cox53, Simon S Cross54, Julie M Cunningham50, Kamila Czene55, Mary B Daly56, Peter Devilee57,58, Kimberly F Doheny59, Thilo Dörk24, Isabel Dos-Santos-Silva60, Martine Dumont61, Miriam Dwek62, Diana M Eccles63, Ursula Eilber18, A Heather Eliassen7,64, Christoph Engel65, Mikael Eriksson55, Laura Fachal19, Peter A Fasching20,66, Jonine Figueroa36,67, Dieter Flesch-Janys68,69, Olivia Fletcher70, Henrik Flyger71, Lin Fritschi72, Marike Gabrielson55, Manuela Gago-Dominguez73,74, Susan M Gapstur43, Montserrat García-Closas36, Mia M Gaudet43, Maya Ghoussaini19, Graham G Giles75,76, Mark S Goldberg77,78, David E Goldgar79, Anna González-Neira21, Pascal Guénel80, Eric Hahnen81,82,83, Christopher A Haiman84, Niclas Håkansson85, Per Hall55,86, Emily Hallberg87, Ute Hamann88, Patricia Harrington19, Alexander Hein20, Belynda Hicks89, Peter Hillemanns24, Antoinette Hollestelle90, Robert N Hoover36, John L Hopper76, Guanmengqian Huang88, Keith Humphreys55, David J Hunter7,91, Anna Jakubowska92,93, Wolfgang Janni94, Esther M John95,96,97, Nichola Johnson70, Kristine Jones89, Michael E Jones98, Audrey Jung18, Rudolf Kaaks18, Michael J Kerin99, Elza Khusnutdinova97,100, Veli-Matti Kosma101,102,103, Vessela N Kristensen104,105,106, Diether Lambrechts107,108, Loic Le Marchand109, Jingmei Li110, Sara Lindström111,112, Jolanta Lissowska113, Wing-Yee Lo32,33, Sibylle Loibl114, Jan Lubinski90, Craig Luccarini19, Michael P Lux20, Robert J MacInnis75,76, Tom Maishman115, Ivana Maleva Kostovska24,116, Arto Mannermaa101,102,103, JoAnn E Manson7,117, Sara Margolin118, Dimitrios Mavroudis119, Hanne Meijers-Heijboer120, Alfons Meindl121, Usha Menon122, Jeffery Meyer50, Anna Marie Mulligan123,124, Susan L Neuhausen125, Heli Nevanlinna126, Patrick Neven127, Sune F Nielsen29,30, Børge G Nordestgaard29,30,31, Olufunmilayo I Olopade128, Janet E Olson87, Håkan Olsson37, Paolo Peterlongo129, Julian Peto60, Dijana Plaseska-Karanfilska116, Ross Prentice16, Nadege Presneau62, Katri Pylkäs130,131, Brigitte Rack94, Paolo Radice132, Nazneen Rahman133, Gad Rennert134, Hedy S Rennert134, Valerie Rhenius19, Atocha Romero41,135, Jane Romm59, Anja Rudolph18, Emmanouil Saloustros136, Dale P Sandler137, Elinor J Sawyer138, Marjanka K Schmidt49,139, Rita K Schmutzler81,82,83, Andreas Schneeweiss39,140, Rodney J Scott141,142, Christopher G Scott87, Sheila Seal133, Mitul Shah19, Martha J Shrubsole1, Ann Smeets127, Melissa C Southey143, John J Spinelli144,145, Jennifer Stone146,147, Harald Surowy39,40, Anthony J Swerdlow98,148, Rulla M Tamimi6,7,64, William Tapper63, Jack A Taylor137,149, Mary Beth Terry150, Daniel C Tessier151, Abigail Thomas87, Kathrin Thöne45, Rob A E M Tollenaar152, Diana Torres88,153, Thérèse Truong80, Michael Untch154, Celine Vachon87, David Van Den Berg84, Daniel Vincent151, Quinten Waisfisz131, Clarice R Weinberg155, Camilla Wendt118, Alice S Whittemore96,97, Hans Wildiers127, Walter C Willett7,64,156, Robert Winqvist130,131, Alicja Wolk85, Lucy Xia84, Xiaohong R Yang36, Argyrios Ziogas13, Elad Ziv157, Alison M Dunning19, Paul D P Pharoah3,19, Jacques Simard61, Roger L Milne75,76, Stacey L Edwards2, Peter Kraft6,7, Douglas F Easton3,19, Georgia Chenevix-Trench158, Wei Zheng159.
Abstract
The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify novel risk loci and likely causal genes, we performed a transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer risk in 122,977 cases and 105,974 controls of European ancestry. We used data from the Genotype-Tissue Expression Project to establish genetic models to predict gene expression in breast tissue and evaluated model performance using data from The Cancer Genome Atlas. Of the 8,597 genes evaluated, significant associations were identified for 48 at a Bonferroni-corrected threshold of P < 5.82 × 10-6, including 14 genes at loci not yet reported for breast cancer. We silenced 13 genes and showed an effect for 11 on cell proliferation and/or colony-forming efficiency. Our study provides new insights into breast cancer genetics and biology.Entities:
Mesh：
Year: 2018 PMID： 29915430 PMCID： PMC6314198 DOI： 10.1038/s41588-018-0132-x
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330