Gianluca M Sampietro1, Francesco Colombo2, Alice Frontali3, Caterina M Baldi2, Stefania Carmagnola4, Andrea Cassinotti4, Alessandra Dell'Era4, Alessandro Massari4, Paola Molteni4, Dario Dilillo5, Paolo Fociani6, Massimo Tonolini7, Giovanni Maconi4, Paolo Fiorina8, Fabio Corsi9, Roberto Bianco7, Manuela Nebuloni6, Gianvincenzo Zuccotti10, Sandro Ardizzone4, Diego Foschi2. 1. IBD Surgical Unit, ASST Fatebenefratelli - Sacco, Milan, Italy; Division of General Surgery, ASST Fatebenefratelli - Sacco, Milan, Italy. Electronic address: gianluca.sampietro@unimi.it. 2. Division of General Surgery, ASST Fatebenefratelli - Sacco, Milan, Italy. 3. Division of Gastroenterology, ASST Fatebenefratelli - Sacco, Milan, Italy; Department of Colorectal Surgery, Pôle des Maladies de l'Appareil Digestif (PMAD), Assistance Publique - Hôpiteau de Paris (AP-HP), Beaujon Hospital, University Denis Diderot, Paris, France. 4. Division of Gastroenterology, ASST Fatebenefratelli - Sacco, Milan, Italy. 5. Division of Pediatrics, ASST Fatebenefratelli - Sacco, Milan, Italy. 6. Division of Pathology, ASST Fatebenefratelli - Sacco, Milan, Italy. 7. Division of Radiology, ASST Fatebenefratelli - Sacco, Milan, Italy. 8. Nephrology Division, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; International Center for T1D, Pediatric Clinical Research Center Fondazione Romeo ed Enrica Invernizzi, Department of Biomedical and Clinical Science L. Sacco, University of Milan, Italy; Division of Endocrinology, ASST Sacco Fatebenefratelli-Sacco, Milan, Italy. 9. Surgery Department, Breast Unit, ICS Maugeri, Pavia, Italy; Department of Biomedical and Clinical Science L. Sacco, University of Milan, Italy. 10. Division of Pediatrics, ASST Fatebenefratelli - Sacco, Milan, Italy; International Center for T1D, Pediatric Clinical Research Center Fondazione Romeo ed Enrica Invernizzi, Department of Biomedical and Clinical Science L. Sacco, University of Milan, Italy.
Abstract
BACKGROUND: Laparoscopic ileo-pouch-anal anastomosis (IPAA) has been reported as having low morbidity and several advantages. AIMS: To evaluate safety, efficacy and long-term results of laparoscopic IPAA, performed in elective or emergency settings, in consecutive unselected IBD patients. METHODS: All the patients received totally laparoscopic 2-stage (proctocolectomy and IPAA - stoma closure) or 3-stage (colectomy - proctectomy and IPAA - stoma closure) procedure according to their presentation. RESULTS: From July 2007 to July 2016, 160 patients entered the study. 50.6% underwent a 3-stage procedure and 49.4% a 2-stage procedure. Mortality and morbidity were 0.6% and 24.6%. Conversion rate was 3.75%. 8.7% septic complications were associated with steroids and Infliximab treatment (p = 0.0001). 3-stage patients were younger (p = 0.0001), with shorter disease duration (p = 0.0001), minor ASA scores of 2 and 3 (p = 0.0007), lower inflammatory index and better nutritional status (p = 0.003 and 0.0001), fewer Clavien-Dindo's grade II complications (p = .0001), reduced rates of readmission and reoperation at 90 days (p = 0.03), and shorter hospitalization (p = .0001), but with similar pouch and IPAA leakage, compared to 2-stage patients. 8 years pouch failure and definitive ileostomy were 5.1% and 3.7%. CONCLUSION: A totally laparoscopic approach is safe and feasible, with very low mortality and morbidity rates and very low conversion rate, even in multi-stage procedures and high-risk patients.
BACKGROUND: Laparoscopic ileo-pouch-anal anastomosis (IPAA) has been reported as having low morbidity and several advantages. AIMS: To evaluate safety, efficacy and long-term results of laparoscopic IPAA, performed in elective or emergency settings, in consecutive unselected IBDpatients. METHODS: All the patients received totally laparoscopic 2-stage (proctocolectomy and IPAA - stoma closure) or 3-stage (colectomy - proctectomy and IPAA - stoma closure) procedure according to their presentation. RESULTS: From July 2007 to July 2016, 160 patients entered the study. 50.6% underwent a 3-stage procedure and 49.4% a 2-stage procedure. Mortality and morbidity were 0.6% and 24.6%. Conversion rate was 3.75%. 8.7% septic complications were associated with steroids and Infliximab treatment (p = 0.0001). 3-stage patients were younger (p = 0.0001), with shorter disease duration (p = 0.0001), minor ASA scores of 2 and 3 (p = 0.0007), lower inflammatory index and better nutritional status (p = 0.003 and 0.0001), fewer Clavien-Dindo's grade II complications (p = .0001), reduced rates of readmission and reoperation at 90 days (p = 0.03), and shorter hospitalization (p = .0001), but with similar pouch and IPAA leakage, compared to 2-stage patients. 8 years pouch failure and definitive ileostomy were 5.1% and 3.7%. CONCLUSION: A totally laparoscopic approach is safe and feasible, with very low mortality and morbidity rates and very low conversion rate, even in multi-stage procedures and high-risk patients.
Authors: G Pellino; D S Keller; G M Sampietro; M Carvello; V Celentano; C Coco; F Colombo; A Geccherle; G Luglio; M Rottoli; M Scarpa; G Sciaudone; G Sica; L Sofo; R Zinicola; S Leone; S Danese; A Spinelli; G Delaini; F Selvaggi Journal: Tech Coloproctol Date: 2020-03-02 Impact factor: 3.781
Authors: Francesco Colombo; Alice Frontali; Caterina Baldi; Maria Cigognini; Giulia Lamperti; Carlo A Manzo; Giovanni Maconi; Sandro Ardizzone; Diego Foschi; Gianluca M Sampietro Journal: Updates Surg Date: 2021-11-01