Georgios Schoretsanitis1,2, Jose de Leon3,4,5, Francisco J Diaz6. 1. University Hospital of Psychiatry, Bern, Switzerland. 2. Department of Psychiatry, Psychotherapy & Psychosomatics, RWTH Aachen University, Aachen, Germany, & JARA - Translational Brain Medicine. 3. University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY 40508, USA. 4. Psychiatry & Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain. 5. Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain. 6. Department of Biostatistics, The University of Kansas Medical Center, Kansas City, KS, USA.
Abstract
AIM: The role of sex on the association of plasma prolactin levels with risperidone (R) and 9-hydroxyrisperidone (9-OHR) concentrations is investigated. METHODS: Plasma R and prolactin concentrations, CYP2D6 and exon 21 and 26 ABCB1 gene variants were studied in 110 patients. RESULTS: In females, a 1 ng/ml increase in R levels was associated with a significant 1.02% increase in prolactin levels. In males, a 1 ng/ml increase in 9-OHR levels was associated with a significant 1.18% increase in prolactin levels. ABCB1 haplotype 12 had significant but opposite effects in males and females. In the combined sample, 9-OHR, but not R levels had significant effects on prolactin levels. CONCLUSION: Genes had sex-specific effects on risperidone-associated prolactin elevations.
AIM: The role of sex on the association of plasma prolactin levels with risperidone (R) and 9-hydroxyrisperidone (9-OHR) concentrations is investigated. METHODS: Plasma R and prolactin concentrations, CYP2D6 and exon 21 and 26 ABCB1 gene variants were studied in 110 patients. RESULTS: In females, a 1 ng/ml increase in R levels was associated with a significant 1.02% increase in prolactin levels. In males, a 1 ng/ml increase in 9-OHR levels was associated with a significant 1.18% increase in prolactin levels. ABCB1 haplotype 12 had significant but opposite effects in males and females. In the combined sample, 9-OHR, but not R levels had significant effects on prolactin levels. CONCLUSION: Genes had sex-specific effects on risperidone-associated prolactin elevations.
Entities:
Keywords:
9-hydroxyrisperidone; ABCB1; CYP2D6; p-glycoprotein; prolactin; risperidone; sex