Literature DB >> 2991430

A herpes simplex virus type 1 mutant with a deletion in the polypeptide-coding sequences of the ICP4 gene.

C H Schröder, J DeZazzo, K W Knopf, H C Kaerner, M Levine, J Glorioso.   

Abstract

A deletion mutant derived from herpes simplex virus type 1 (HSV-1) strain ANG was analysed. The deletion mapped within the polypeptide-coding region of the immediate-early ICP4 gene. Based on DNA sequence data the deletion was shown to comprise 84 base pairs. In the wild-type genome of strain ANG these sequences were almost completely homologous to the known sequences of HSV-1 strain 17. The ICP4 polypeptide induced by the mutant was similar in size to the wild-type ICP4 protein and was recognized by a monoclonal antibody against ICP4. The data presented suggest that the deletion corresponds to a region on the ICP4 polypeptide that is nonessential for the replication of the virus in vitro.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2991430     DOI： 10.1099/0022-1317-66-7-1589

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  8 in total

1.  Codons 262 to 490 from the herpes simplex virus ICP4 gene are sufficient to encode a sequence-specific DNA binding protein.

Authors:  C L Wu; K W Wilcox
Journal:  Nucleic Acids Res       Date:  1990-02-11       Impact factor: 16.971

2.  Identification of a promoter-specific transactivation domain in the herpes simplex virus regulatory protein ICP4.

Authors:  W Xiao; L I Pizer; K W Wilcox
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

3.  DNA binding by the herpes simplex virus type 1 ICP4 protein is necessary for efficient down regulation of the ICP0 promoter.

Authors:  J Resnick; B A Boyd; M L Haffey
Journal:  J Virol       Date:  1989-06       Impact factor: 5.103

4.  Physical and functional domains of the herpes simplex virus transcriptional regulatory protein ICP4.

Authors:  N A DeLuca; P A Schaffer
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

5.  Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1.

Authors:  D J McGeoch; A Dolan; S Donald; D H Brauer
Journal:  Nucleic Acids Res       Date:  1986-02-25       Impact factor: 16.971

6.  Separation of primary structural components conferring autoregulation, transactivation, and DNA-binding properties to the herpes simplex virus transcriptional regulatory protein ICP4.

Authors:  A A Shepard; A N Imbalzano; N A DeLuca
Journal:  J Virol       Date:  1989-09       Impact factor: 5.103

7.  Activities of herpes simplex virus type 1 (HSV-1) ICP4 genes specifying nonsense peptides.

Authors:  N A DeLuca; P A Schaffer
Journal:  Nucleic Acids Res       Date:  1987-06-11       Impact factor: 16.971

8.  Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4.

Authors:  N A DeLuca; A M McCarthy; P A Schaffer
Journal:  J Virol       Date:  1985-11       Impact factor: 5.103
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.