Guocan Yu1, Jie Yang2, Xiao Fu1, Zhantong Wang1, Li Shao2, Zhengwei Mao3, Yijing Liu1, Zhen Yang1, Fuwu Zhang1, Wenpei Fan1, Jibin Song1, Zijian Zhou1, Changyou Gao3, Feihe Huang2, Xiaoyuan Chen1. 1. Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States. 2. State Key Laboratory of Chemical Engineering, Center for Chemistry of High-Performance & Novel Materials, Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China. 3. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China.
Abstract
Photoacoustic imaging combines the merits of ultrasound imaging and optical imaging that allows a fascinating imaging paradigm with deeper tissue penetration than optical imaging and higher spatial resolution than ultrasound imaging. Herein, we develop a supramolecular hybrid material composed of graphene oxide (GO) and a pillar[6]arene-based host-guest complex (CP6⊃PyN), which can be used as a ultrasound (US) and photoacoustic (PA) signal nanoamplifier. Triggered by the near-infrared (NIR) light mediated photothermal effect, CO2 nanobubbles are generated on the surface of GO@CP6⊃PyN due to the decomposition of bicarbonate counterions, thus strongly amplifying its US and PA performances. Our study, for the first time, demonstrates enhanced US and PA activity in supramolecular hybrid material on the basis of host-guest chemistry as a photoacoustic nanoplatform.
Photoacoustic imaging combines the merits of ultrasound imaging and optical imaging that allows a fascinating imaging paradigm with deeper tissue penetration than optical imaging and higher spatial resolution than ultrasound imaging. Herein, we develop a supramolecular hybrid material composed of pan class="Chemical">graphene oxide (GO) and a pillar[6]pan class="Chemical">arene-based host-guest complex (CP6⊃PyN), which can be used as a ultrasound (US) and photoacoustic (PA) signal nanoamplifier. Triggered by the near-infrared (NIR) light mediated photothermal effect, CO2 nanobubbles are generated on the surface of GO@CP6⊃PyN due to the decomposition of bicarbonate counterions, thus strongly amplifying its US and PA performances. Our study, for the first time, demonstrates enhanced US and PA activity in supramolecular hybrid material on the basis of host-guest chemistry as a photoacoustic nanoplatform.
Authors: Nathan L Strutt; Ross S Forgan; Jason M Spruell; Youssry Y Botros; J Fraser Stoddart Journal: J Am Chem Soc Date: 2011-03-28 Impact factor: 15.419
Authors: Al de Leon; Peiran Wei; Filip Bordera; Dana Wegierak; Madelyn McMillen; David Yan; Christina Hemmingsen; Michael C Kolios; Emily B Pentzer; Agata A Exner Journal: ACS Appl Mater Interfaces Date: 2020-05-01 Impact factor: 9.229