Literature DB >> 2991057

Induction of undifferentiated brain tumors in rats by a human polyomavirus (JC virus).

S Ohsumi, I Ikehara, M Motoi, K Ogawa, K Nagashima, K Yasui.   

Abstract

Newborn SD rats were inoculated intracranially with JC virus (Tokyo-1), a human polyomavirus, isolated from the autopsied brain of a patient with progressive multifocal leukoencephalopathy. Twenty-one to 61 weeks later, 20 of 27 rats developed tumors in the cerebrum, but not in the cerebellum. The undifferentiated neuroectodermal nature of the tumors was histologically, immunohistochemically and ultrastructurally confirmed.

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Year:  1985        PMID: 2991057

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN: 0910-5050


  13 in total

Review 1.  Brain tumors and polyomaviruses.

Authors:  Sidney Croul; Jessica Otte; Kamel Khalili
Journal:  J Neurovirol       Date:  2003-04       Impact factor: 2.643

2.  Detection of human polyomavirus proteins, T-antigen and agnoprotein, in human tumor tissue arrays.

Authors:  Luis Del Valle; Kamel Khalili
Journal:  J Med Virol       Date:  2010-05       Impact factor: 2.327

3.  Analysis of capsid formation of human polyomavirus JC (Tokyo-1 strain) by a eukaryotic expression system: splicing of late RNAs, translation and nuclear transport of major capsid protein VP1, and capsid assembly.

Authors:  Y Shishido-Hara; Y Hara; T Larson; K Yasui; K Nagashima; G L Stoner
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

4.  Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas.

Authors:  B Krynska; L Del Valle; S Croul; J Gordon; C D Katsetos; M Carbone; A Giordano; K Khalili
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

Review 5.  Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain.

Authors:  Michael W Ferenczy; Leslie J Marshall; Christian D S Nelson; Walter J Atwood; Avindra Nath; Kamel Khalili; Eugene O Major
Journal:  Clin Microbiol Rev       Date:  2012-07       Impact factor: 26.132

Review 6.  Molecular genetics of pineal region neoplasms.

Authors:  M D Taylor; T G Mainprize; J A Squire; J T Rutka
Journal:  J Neurooncol       Date:  2001-09       Impact factor: 4.130

7.  Immune response to JC virus T antigen in patients with and without colorectal neoplasia.

Authors:  Lindsay D Butcher; Melissa Garcia; Mildred Arnold; Hideki Ueno; Ajay Goel; C Richard Boland
Journal:  Gut Microbes       Date:  2014-07-09

8.  Novel polyomavirus associated with brain tumors in free-ranging raccoons, western United States.

Authors:  Florante N Dela Cruz; Federico Giannitti; Linlin Li; Leslie W Woods; Luis Del Valle; Eric Delwart; Patricia A Pesavento
Journal:  Emerg Infect Dis       Date:  2013-01       Impact factor: 6.883

Review 9.  Human polyomavirus reactivation: disease pathogenesis and treatment approaches.

Authors:  Cillian F De Gascun; Michael J Carr
Journal:  Clin Dev Immunol       Date:  2013-05-02

10.  Activation of c-Myc and Cyclin D1 by JCV T-Antigen and β-catenin in colon cancer.

Authors:  Michael J Ripple; Amanda Parker Struckhoff; Jimena Trillo-Tinoco; Li Li; David A Margolin; Robin McGoey; Luis Del Valle
Journal:  PLoS One       Date:  2014-09-17       Impact factor: 3.240

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