OBJECTIVE: In the presented study, we aimed to systematically analyze plasma proteomes in cord blood samples from preterm infants stratified by their gestational age to identify proteins and related malfunctioning pathways at birth, possibly contributing to the complications observed among preterm infants. STUDY DESIGN: Preterm newborns were enrolled of three subgroups with different gestation age: newborns born ≤26 (group 1), between 27 and 28 (group 2) and between 29 and 30 (group 3) weeks of gestation, respectively, and compared to the control group of healthy, full-term newborns in respect to their plasma proteome composition. RESULT: Preterm delivery is associated with multiple protein abundance changes in plasma related to a plethora of processes, including inflammation and immunomodulation, coagulation, and complement activation as some key features. CONCLUSION: Plasma proteome analysis revealed numerous gestation-age-dependent protein abundance differences between term and preterm infants, which highlight key dysregulated pathways and potential new protein treatment targets.
OBJECTIVE: In the presented study, we aimed to systematically analyze plasma proteomes in cord blood samples from preterm infants stratified by their gestational age to identify proteins and related malfunctioning pathways at birth, possibly contributing to the complications observed among preterm infants. STUDY DESIGN: Preterm newborns were enrolled of three subgroups with different gestation age: newborns born ≤26 (group 1), between 27 and 28 (group 2) and between 29 and 30 (group 3) weeks of gestation, respectively, and compared to the control group of healthy, full-term newborns in respect to their plasma proteome composition. RESULT: Preterm delivery is associated with multiple protein abundance changes in plasma related to a plethora of processes, including inflammation and immunomodulation, coagulation, and complement activation as some key features. CONCLUSION: Plasma proteome analysis revealed numerous gestation-age-dependent protein abundance differences between term and preterm infants, which highlight key dysregulated pathways and potential new protein treatment targets.
Authors: Saima Ahmed; Oludare A Odumade; Patrick van Zalm; Kinga K Smolen; Kimino Fujimura; Jan Muntel; Melissa S Rotunno; Abigail B Winston; Judith A Steen; Richard B Parad; Linda J Van Marter; Stella Kourembanas; Hanno Steen Journal: Neonatology Date: 2022-01-24 Impact factor: 4.035
Authors: Magdalena Zasada; Maciej Suski; Renata Bokiniec; Monika Szwarc-Duma; Maria Katarzyna Borszewska-Kornacka; Józef Madej; Beata Bujak-Giżycka; Anna Madetko-Talowska; Cecilie Revhaug; Lars O Baumbusch; Ola D Saugstad; Jacek Józef Pietrzyk; Przemko Kwinta Journal: Ital J Pediatr Date: 2019-08-24 Impact factor: 2.638
Authors: Philip L Ballard; Juan Oses-Prieto; Cheryl Chapin; Mark R Segal; Roberta A Ballard; Alma L Burlingame Journal: PLoS One Date: 2020-12-10 Impact factor: 3.240
Authors: Natasha Letunica; Tengyi Cai; Jeanie L Y Cheong; Lex W Doyle; Paul Monagle; Vera Ignjatovic Journal: Clin Proteomics Date: 2021-04-14 Impact factor: 3.988
Authors: Kristin Leifsdottir; Kerstin Jost; Veronica Siljehav; Eric P Thelin; Philipp Lassarén; Peter Nilsson; Ásgeir Haraldsson; Staffan Eksborg; Eric Herlenius Journal: Front Pediatr Date: 2022-07-19 Impact factor: 3.569