Jean-Pierre Lindenmayer1, Anzalee Khan2, Susan R McGurk3, Mila Kirstie C Kulsa4, Isidora Ljuri5, Veronica Ozog6, Samantha Fregenti7, Gianna Capodilupo8, Kiara Buccellato9, Amod Thanju10, Abraham Goldring11, Mohan Parak12, Benedicto Parker13. 1. Manhattan Psychiatric Center, 600 East 125th Street Wards Island, New York, NY 10035, United States; Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, United States; New York University School of Medicine, 550 1st Avenue, New York, NY 10016, United States. Electronic address: Jean-Pierre.Lindenmayer@omh.ny.gov. 2. Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, United States; NeuroCog Trials, 3211 Shannon Road #300, Durham, NC 27707, United States. Electronic address: Anzalee.Khan@neurocogtrials.com. 3. Boston University, 1 Silber Way, Boston, MA 02215, United States. Electronic address: Mcgurk@bu.edu. 4. Manhattan Psychiatric Center, 600 East 125th Street Wards Island, New York, NY 10035, United States; Teachers College Columbia University, 525 West 120th Street, New York, NY 10027, United States. Electronic address: Mck2177@tc.columbia.edu. 5. Manhattan Psychiatric Center, 600 East 125th Street Wards Island, New York, NY 10035, United States. Electronic address: Isidora.Ljuri@omh.ny.gov. 6. Adelphi University, 1 South Avenue, Garden City, NY 11530, United States. Electronic address: vao2104@tc.columbia.edu. 7. Mental Health Service Corps, 425 East 25th Street, New York, NY 10010, United States. Electronic address: sefreg13@g.holycross.edu. 8. MedAvante-ProPhase, 3 Park Avenue, New York, NY 10016, United States. 9. Henry Jackson Foundation at The Walter Reed National Military Medical Center, 901 Rockville Pike, Bethesda, MD 20889, United States. 10. Manhattan Psychiatric Center, 600 East 125th Street Wards Island, New York, NY 10035, United States; Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, United States. Electronic address: Amod.Thanju@omh.ny.gov. 11. Manhattan Psychiatric Center, 600 East 125th Street Wards Island, New York, NY 10035, United States; Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, United States. Electronic address: Abraham.Goldring@omh.ny.gov. 12. Manhattan Psychiatric Center, 600 East 125th Street Wards Island, New York, NY 10035, United States; Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, United States. Electronic address: Mohan.Parak@omh.ny.gov. 13. Manhattan Psychiatric Center, 600 East 125th Street Wards Island, New York, NY 10035, United States. Electronic address: Benedicto.Parker@omh.ny.gov.
Abstract
OBJECTIVES:Cognitive remediation therapy (CRT) has shown significant improvement in cognition in schizophrenia. However, effect sizes of CRT have been reported to be modest raising the issue how to augment the effects of CRT on neurocognition and social cognition. Our aim was to examine whether the addition of computerized social cognition training would enhance the effects on neurocognition and social cognition as compared to CRT alone. METHODS: This is a 12-week, parallel group trial of 131 in- and out-patients with schizophrenia randomized toCRT (COGPACK or Brain Fitness) with computerized social cognition training (MRIGE), or CRT alone for 36 sessions. Participants were assessed at baseline and after 12 weeks of treatment. Assessments included neurocognition, social cognition, psychopathology, and functioning. RESULTS: The combined intervention, CRT + MRIGE, showed greater improvements in the MCCB indices of Visual Learning, Working Memory, Reasoning and Problem-Solving, and the neurocognitive composite score compared to CRT alone (Bonferroni adjusted p = 0.004, p = 0.005, p = 0.01, respectively), as did social cognition measures (Bonferroni adjusted p = 0.006, p = 0.005, respectively). CONCLUSIONS:Supplementing CRT with computerized social cognition training produced greater benefits in neurocognition, including visual learning, memory, executive functions, and social cognition relative to cognitive training alone. These findings favoring the combined training may be contributed to both the greater overall amount of cognitive practice, as well as the specific cognitive functions engaged by the social cognition training.
RCT Entities:
OBJECTIVES: Cognitive remediation therapy (CRT) has shown significant improvement in cognition in schizophrenia. However, effect sizes of CRT have been reported to be modest raising the issue how to augment the effects of CRT on neurocognition and social cognition. Our aim was to examine whether the addition of computerized social cognition training would enhance the effects on neurocognition and social cognition as compared to CRT alone. METHODS: This is a 12-week, parallel group trial of 131 in- and out-patients with schizophrenia randomized to CRT (COGPACK or Brain Fitness) with computerized social cognition training (MRIGE), or CRT alone for 36 sessions. Participants were assessed at baseline and after 12 weeks of treatment. Assessments included neurocognition, social cognition, psychopathology, and functioning. RESULTS: The combined intervention, CRT + MRIGE, showed greater improvements in the MCCB indices of Visual Learning, Working Memory, Reasoning and Problem-Solving, and the neurocognitive composite score compared to CRT alone (Bonferroni adjusted p = 0.004, p = 0.005, p = 0.01, respectively), as did social cognition measures (Bonferroni adjusted p = 0.006, p = 0.005, respectively). CONCLUSIONS: Supplementing CRT with computerized social cognition training produced greater benefits in neurocognition, including visual learning, memory, executive functions, and social cognition relative to cognitive training alone. These findings favoring the combined training may be contributed to both the greater overall amount of cognitive practice, as well as the specific cognitive functions engaged by the social cognition training.
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