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Literature DB >> 2990993

Failure of calcium to stimulate Na,K-ATPase in the presence of EDTA.

Abstract

The effect of calcium on Na,K-ATPase activity of rat brain homogenates and its modification by the chelating agent EDTA has been investigated. In the absence of EDTA, free calcium (approximately 10(-6) mol/l) stimulates Na,K-ATPase activity; in the presence of EDTA the same concentration of free calcium is without effect on the enzyme. In the absence of EDTA the stimulation by calcium of Na,K-ATPase activity is enhanced by the additional presence of calmodulin but in the presence of EDTA, even when calmodulin is added to excess, calcium still fails to stimulate the enzyme. The possibility that EDTA interferes with an interaction between a calcium-calmodulin complex and Na,K-ATPase is discussed.

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Year: 1985 PMID： 2990993 DOI： 10.1007/bf01952137

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

11 in total

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Authors: T Tobin; T Akera; S I Baskin; T M Brody
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9. Determination of the stability constants of Mn2+ and Mg2+ complexes of the components of the NADP-linked isocitrate dehydrogenase reaction by electron spin resonance.

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Journal: Eur J Biochem Date: 1980-09

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Authors: F H Epstein; R Whittam
Journal: Biochem J Date: 1966-04 Impact factor: 3.857

2 in total

1. Ultrahistochemical localization of Na+-K+ ATPase, Ca2+-ATPase and alkaline phosphatase activity in a calcium-transporting epithelium of a crustacean during moulting.

Authors: J C Meyran; F Graf
Journal: Histochemistry Date: 1986

2. The effect of EGTA and Ca++ in regulation of the brain Na/K-ATPase by noradrenaline.

Authors: S Abashidze; T Jariashvili; Z Kometiani
Journal: BMC Biochem Date: 2001-09-03 Impact factor: 4.059