Literature DB >> 29909913

GMP CAR-T cell production.

Adrian P Gee1.   

Abstract

The clinical success achieved using CD19-directed CAR-T cells has stimulated many academic institutions to explore the feasibility of manufacturing these, and other CAR-T cells, in-house. This article reviews the issues that must be addressed in order to achieve this goal. It includes the manufacturing infrastructure, the regulatory environment, practical aspects of production, and the costs involved.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  CAR-T cells; Good manufacturing practices; Manufacturing

Mesh：

Substances：

Year:  2018        PMID： 29909913     DOI： 10.1016/j.beha.2018.01.002

Source DB:  PubMed          Journal:  Best Pract Res Clin Haematol        ISSN： 1521-6926            Impact factor:   3.020


  9 in total

Review 1.  Influence of Culture Conditions on Ex Vivo Expansion of T Lymphocytes and Their Function for Therapy: Current Insights and Open Questions.

Authors:  Harish Sudarsanam; Raymund Buhmann; Reinhard Henschler
Journal:  Front Bioeng Biotechnol       Date:  2022-06-29

Review 2.  Claudin18.2 is a novel molecular biomarker for tumor-targeted immunotherapy.

Authors:  Weijie Cao; Haizhou Xing; Yingmei Li; Wenliang Tian; Yongping Song; Zhongxing Jiang; Jifeng Yu
Journal:  Biomark Res       Date:  2022-05-31

Review 3.  CAR T-Cell Production Using Nonviral Approaches.

Authors:  Viktor Lukjanov; Irena Koutná; Pavel Šimara
Journal:  J Immunol Res       Date:  2021-03-27       Impact factor: 4.818

Review 4.  Strategies to Overcome Failures in T-Cell Immunotherapies by Targeting PI3K-δ and -γ.

Authors:  Sanjay Chandrasekaran; Christopher Ronald Funk; Troy Kleber; Chrystal M Paulos; Mala Shanmugam; Edmund K Waller
Journal:  Front Immunol       Date:  2021-08-26       Impact factor: 7.561

Review 5.  Cytokines as an important player in the context of CAR-T cell therapy for cancer: Their role in tumor immunomodulation, manufacture, and clinical implications.

Authors:  Caio Raony Farina Silveira; Amanda Cristina Corveloni; Sâmia Rigotto Caruso; Nathália Araújo Macêdo; Natália Moscheta Brussolo; Felipe Haddad; Taisa Risque Fernandes; Pamela Viani de Andrade; Maristela Delgado Orellana; Renato Luiz Guerino-Cunha
Journal:  Front Immunol       Date:  2022-09-12       Impact factor: 8.786

Review 6.  Gene therapy approaches for equine osteoarthritis.

Authors:  Parvathy Thampi; R Jude Samulski; Joshua C Grieger; Jennifer N Phillips; C Wayne McIlwraith; Laurie R Goodrich
Journal:  Front Vet Sci       Date:  2022-09-28

7.  Optical Control of CD8+ T Cell Metabolism and Effector Functions.

Authors:  Andrea M Amitrano; Brandon J Berry; Kihong Lim; Kyun-Do Kim; Richard E Waugh; Andrew P Wojtovich; Minsoo Kim
Journal:  Front Immunol       Date:  2021-06-03       Impact factor: 7.561

8.  Establishment and validation of in-house cryopreserved CAR/TCR-T cell flow cytometry quality control.

Authors:  Yihua Cai; Michaela Prochazkova; Chunjie Jiang; Hannah W Song; Jianjian Jin; Larry Moses; Nikolaos Gkitsas; Robert P Somerville; Steven L Highfill; Sandhya Panch; David F Stroncek; Ping Jin
Journal:  J Transl Med       Date:  2021-12-24       Impact factor: 5.531

9.  One-Time Optimization of Advanced T Cell Culture Media Using a Machine Learning Pipeline.

Authors:  Paul Grzesik; Sebastian C Warth
Journal:  Front Bioeng Biotechnol       Date:  2021-07-15
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.