F López1, J L Hunt2, I J Nixon3, A Rinaldo4, M D Williams5, A Cardesa6, A Ferlito7. 1. Department of Otolaryngology,Hospital Universitario Central de Asturias,Oviedo,Spain. 2. Department of Pathology,University of Arkansas for Medical Sciences,Little Rock,USA. 3. Department of Otolaryngology Head and Neck Surgery,NHS Lothian, Edinburgh,UK. 4. University of Udine School of Medicine,Udine,Italy. 5. Department of Pathology,University of Texas MD Anderson Cancer Center,Houston,USA. 6. Department of Anatomic Pathology,Hospital Clinic, University of Barcelona,Spain. 7. Coordinator of the International Head and Neck Scientific Group,Padua,Italy.
Abstract
OBJECTIVE: This review aimed to critically analyse data pertaining to the clinical presentation and treatment of neuroendocrine carcinomas of the larynx. METHOD: A PubMed search was performed using the term 'neuroendocrine carcinoma'. English-language articles on neuroendocrine carcinoma of the larynx were reviewed in detail.Results and conclusionWhile many historical classifications have been proposed, in contemporary practice these tumours are sub-classified into four subtypes: carcinoid, atypical carcinoid, small cell neuroendocrine carcinoma and large cell neuroendocrine carcinoma. These tumours exhibit a wide range of biological behaviour, ranging from the extremely aggressive nature of small and large cell neuroendocrine carcinomas, which usually have a fatal prognosis, to the less aggressive course of carcinoid tumours. In small and large cell neuroendocrine carcinomas, a combination of irradiation and chemotherapy is indicated, while carcinoid and atypical carcinoid tumour management entails conservation surgery.
OBJECTIVE: This review aimed to critically analyse data pertaining to the clinical presentation and treatment of neuroendocrine carcinomas of the larynx. METHOD: A PubMed search was performed using the term 'neuroendocrine carcinoma'. English-language articles on neuroendocrine carcinoma of the larynx were reviewed in detail.Results and conclusionWhile many historical classifications have been proposed, in contemporary practice these tumours are sub-classified into four subtypes: carcinoid, atypical carcinoid, small cell neuroendocrine carcinoma and large cell neuroendocrine carcinoma. These tumours exhibit a wide range of biological behaviour, ranging from the extremely aggressive nature of small and large cell neuroendocrine carcinomas, which usually have a fatal prognosis, to the less aggressive course of carcinoid tumours. In small and large cell neuroendocrine carcinomas, a combination of irradiation and chemotherapy is indicated, while carcinoid and atypical carcinoid tumour management entails conservation surgery.
Authors: Anas Bouzbouz; Bushra Abdulhakeem; Rabii Laababsi; Sami Rouadi; Reda Abada; Mohamed Roubal; Mohamed Mahtar Journal: Int J Surg Case Rep Date: 2019-12-13