Literature DB >> 29909639

Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes.

Gregory Beutner1, Ronald Carrasquillo1, Peng Geng1, Yi Hsiao1, Eric C Huang1, Jacob Janey1, Kishta Katipally1, Sergei Kolotuchin1, Thomas La Porte1, Andrew Lee1, Paul Lobben1, Federico Lora-Gonzalez1, Brendan Mack1, Boguslaw Mudryk1, Yuping Qiu1, Xinhua Qian1, Antonio Ramirez1, Thomas M Razler1, Thorsten Rosner1, Zhongping Shi1, Eric Simmons1, Jason Stevens1, Jianji Wang1, Carolyn Wei1, Steven R Wisniewski1, Ye Zhu1.   

Abstract

A strategy to prepare compounds with multiple chirality axes, which has led to a concise total synthesis of compound 1A with complete stereocontrol, is reported.

Year:  2018        PMID： 29909639     DOI： 10.1021/acs.orglett.8b01218

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

1.  Global Substance Registration System: consistent scientific descriptions for substances related to health.

Authors:  Tyler Peryea; Noel Southall; Mitch Miller; Daniel Katzel; Niko Anderson; Jorge Neyra; Sarah Stemann; Ðắc-Trung Nguyễn; Dammika Amugoda; Archana Newatia; Ramez Ghazzaoui; Elaine Johanson; Herman Diederik; Larry Callahan; Frank Switzer
Journal:  Nucleic Acids Res       Date:  2021-01-08       Impact factor: 16.971

2.  Next-Generation Total Synthesis of Vancomycin.

Authors:  Maxwell J Moore; Shiwei Qu; Ceheng Tan; Yu Cai; Yuzo Mogi; D Jamin Keith; Dale L Boger
Journal:  J Am Chem Soc       Date:  2020-09-04       Impact factor: 15.419

3.  Troponoid Atropisomerism: Studies on the Configurational Stability of Tropone-Amide Chiral Axes.

Authors:  Danielle R Hirsch; Anthony J Metrano; Elizabeth A Stone; Golo Storch; Scott J Miller; Ryan P Murelli
Journal:  Org Lett       Date:  2019-03-14       Impact factor: 6.005

4.  Carbene-catalyzed atroposelective synthesis of axially chiral styrenes.

Authors:  Jia-Lei Yan; Rakesh Maiti; Shi-Chao Ren; Weiyi Tian; Tingting Li; Jun Xu; Bivas Mondal; Zhichao Jin; Yonggui Robin Chi
Journal:  Nat Commun       Date:  2022-01-10       Impact factor: 14.919

5.  Enantioselective construction of ortho-sulfur- or nitrogen-substituted axially chiral biaryls and asymmetric synthesis of isoplagiochin D.

Authors:  He Yang; Wenjun Tang
Journal:  Nat Commun       Date:  2022-08-05       Impact factor: 17.694

6.  Multilayer 3D Chirality and Its Synthetic Assembly.

Authors:  Guanzhao Wu; Yangxue Liu; Zhen Yang; Nandakumar Katakam; Hossein Rouh; Sultan Ahmed; Daniel Unruh; Kazimierz Surowiec; Guigen Li
Journal:  Research (Wash D C)       Date:  2019-06-27

7.  Bidirectional enantioselective synthesis of bis-benzofuran atropisomeric oligoarenes featuring two distal C-C stereogenic axes.

Authors:  Xiaoze Bao; Jean Rodriguez; Damien Bonne
Journal:  Chem Sci       Date:  2019-11-20       Impact factor: 9.825
  7 in total

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