Alexander G Weil1, Katherine Muir2, Juliette Hukin3, Alex Desautels4, Véronique Martel5, Sébastien Perreault6. 1. Pediatric Neurosurgery Service, Department of Surgery, CHU Sainte-Justine, University of Montreal, Montreal, Quebec, Canada. 2. Division of Child Neurology, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. 3. Division of Child Neurology and Oncology, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. 4. Division of Neurology and Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur, University of Montreal, Montreal, Quebec, Canada. 5. Division of Child Neurology, Department of Pediatrics, CHU Sainte-Justine, University of Montreal, Montreal, Quebec, Canada. 6. Division of Child Neurology, Department of Pediatrics, CHU Sainte-Justine, University of Montreal, Montreal, Quebec, Canada. Electronic address: s.perreault@umontreal.ca.
Abstract
OBJECTIVE: Because most cases of brain tumor-associated narcolepsy have been published in the form of case reports or small series, the clinical presentation and evolution have not been well described. We sought to better define the epidemiology, etiology, and outcome of brain tumor-related narcolepsy. METHODS: We conducted an extensive review of the literature to identify cases of narcolepsy associated with brain tumors. Only cases of brain tumors involving the hypothalamic region including the suprasellar, sellar, and thalamus were included in this study. RESULTS: We report a child with possible narcolepsy in a child with a brain tumor. Through our literature review, we identified 25 additional cases of narcolepsy associated with brain tumors affecting the hypothalamic area. Most symptomatic narcolepsy cases were reported in children (70%). Half of the patients (13 of 25, 52%) developed narcolepsy after surgery, whereas 11 patients (44%) were symptomatic at the time of the tumor diagnosis. Ten patients had narcolepsy without cataplexy. Most cases were associated with craniopharyngioma (38%), adenoma (24%), and glioma (14%). Three, including our patient, experienced a complete resolution of symptoms. All patients underwent biopsy and were treated with adjuvant therapy. For patients with persistent symptoms, most (60%) improved following medical management of narcolepsy. CONCLUSION: This study represents the largest compilation of patients with this association. Our study allows us to better understand the etiology and outcome of patients with narcolepsy-related brain tumors.
OBJECTIVE: Because most cases of brain tumor-associated narcolepsy have been published in the form of case reports or small series, the clinical presentation and evolution have not been well described. We sought to better define the epidemiology, etiology, and outcome of brain tumor-related narcolepsy. METHODS: We conducted an extensive review of the literature to identify cases of narcolepsy associated with brain tumors. Only cases of brain tumors involving the hypothalamic region including the suprasellar, sellar, and thalamus were included in this study. RESULTS: We report a child with possible narcolepsy in a child with a brain tumor. Through our literature review, we identified 25 additional cases of narcolepsy associated with brain tumors affecting the hypothalamic area. Most symptomatic narcolepsy cases were reported in children (70%). Half of the patients (13 of 25, 52%) developed narcolepsy after surgery, whereas 11 patients (44%) were symptomatic at the time of the tumor diagnosis. Ten patients had narcolepsy without cataplexy. Most cases were associated with craniopharyngioma (38%), adenoma (24%), and glioma (14%). Three, including our patient, experienced a complete resolution of symptoms. All patients underwent biopsy and were treated with adjuvant therapy. For patients with persistent symptoms, most (60%) improved following medical management of narcolepsy. CONCLUSION: This study represents the largest compilation of patients with this association. Our study allows us to better understand the etiology and outcome of patients with narcolepsy-related brain tumors.
Authors: Maria P Mogavero; Filomena I I Cosentino; Bartolo Lanuzza; Mariangela Tripodi; Giuseppe Lanza; Debora Aricò; Lourdes M DelRosso; Fabio Pizza; Giuseppe Plazzi; Raffaele Ferri Journal: Brain Sci Date: 2021-11-28
Authors: Simone Rossi; Gian Maria Asioli; Giovanni Rizzo; Giombattista Sallemi; Monica Moresco; Christian Franceschini; Fabio Pizza; Giuseppe Plazzi Journal: J Clin Sleep Med Date: 2021-12-01 Impact factor: 4.062